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Identifying correlates of risk for future tuberculosis disease progression in children (INTREPID)

Award Number: R01AI175235
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/05/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Identifying correlates of risk for future tuberculosis disease progression in children (INTREPID) - Young children and those living with HIV are at the highest risk of progressing from Mtb exposure to tuberculosis (TB) disease and of developing severe forms of TB. We will use stored samples from young children already recruited to longitudinal clinical TB studies and use transcriptomics, proteomics, metabolomics, and antibody approaches to identify biomarkers associated with progression to TB disease and treatment response. We will integrate the different approaches, together with information on viral coinfection and clinical and epidemiological covariates, to identify the optimal signatures to allow targeted TB preventive therapy. These results will have direct clinical applications for the management of children exposed to TB in the United States and globally.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $504,754 )
2026	2026	STELLENBOSCH UNIVERSITY	ADMINISTRATION BUILDING B, VICTORIA ST	STELLENBOSCH				ZAF	Allergy and Infectious Diseases Research	000	4	5/7/2026	NON-COMPETING CONTINUATION	$504,754
														Subtotal = $504,754

Issue Date FY: 2025 ( Subtotal = $793,228 )
2025	2025	STELLENBOSCH UNIVERSITY	ADMINISTRATION BUILDING B, VICTORIA ST	STELLENBOSCH				ZAF	Allergy and Infectious Diseases Research	002	3	9/24/2025	SUPPLEMENT FOR EXPANSION	$28,397
2025	2025	STELLENBOSCH UNIVERSITY	ADMINISTRATION BUILDING B, VICTORIA ST	STELLENBOSCH				ZAF	Allergy and Infectious Diseases Research	001	3	9/23/2025	SUPPLEMENT FOR EXPANSION	$255,081
2025	2025	STELLENBOSCH UNIVERSITY	ADMINISTRATION BUILDING B, VICTORIA ST	STELLENBOSCH				ZAF	Allergy and Infectious Diseases Research	000	3	9/19/2025	NON-COMPETING CONTINUATION	$509,750
														Subtotal = $793,228

Issue Date FY: 2024 ( Subtotal = $806,256 )
2024	2024	STELLENBOSCH UNIVERSITY	ADMINISTRATION BUILDING B, VICTORIA ST	STELLENBOSCH				ZAF	Allergy and Infectious Diseases Research	001	2	3/19/2024	NON-COMPETING CONTINUATION	$806,256
2024	2024	STELLENBOSCH UNIVERSITY	ADMINISTRATION BUILDING B, VICTORIA ST	STELLENBOSCH				ZAF	Allergy and Infectious Diseases Research	002	2	7/19/2024	NON-COMPETING CONTINUATION	$0
2024	2023	STELLENBOSCH UNIVERSITY	ADMINISTRATION BUILDING B, VICTORIA ST	STELLENBOSCH				ZAF	Allergy and Infectious Diseases Research	000	1	1/10/2024	NEW	$0
														Subtotal = $806,256

Issue Date FY: 2023 ( Subtotal = $840,947 )
2023	2023	UNIVERSITEIT STELLENBOSCH	ADMINISTRATION BUILDING B, VICTORIA STREET	STELLENBOSCH				ZAF	Allergy and Infectious Diseases Research	000	1	5/5/2023	NEW	$840,947
														Subtotal = $840,947

Grand Total All Awards = $2,945,185

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Identifying correlates of risk for future tuberculosis disease progression in children (INTREPID)

Award Number: R01AI175235

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/05/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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