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Mechanisms of White-Opaque Switching in Candida albicans

Award Number: R01AI175080
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/06/2023
PERIOD OF PERFORMANCE END DATE: 10/31/2028

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Mechanisms of White-Opaque Switching in Candida albicans - Project Summary/Abstract Candida albicans is one of the most prevalent fungal pathogen of humans and also a component of the human microbiome; it can cause superficial infections in normal humans and life-threatening systemic infections in immune compromised individuals. Our work seeks to understand how C. albicans regulates its genes so it can survive and proliferate in the many different environments of its human host. This proposal focuses on a single, large transcription circuit—the white-opaque switching circuit—which allows two different cell-types to be produced epigenetically from the same genome. White-opaque switching is deeply conserved across clinical isolates of C. albicans and is also observed in closely related Candida species. This proposal seeks to understand the mechanism behind white-opaque switching, the mechanisms underlying the stability of the two distinct, epigenetic cell-types and the effects of white-opaque switching on Candida’s ability to thrive in its mammalian hosts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $727,285 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	3	11/24/2025	NON-COMPETING CONTINUATION	$727,285
														Subtotal = $727,285

Issue Date FY: 2025 ( Subtotal = $705,466 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	2	11/4/2024	NON-COMPETING CONTINUATION	$705,466
														Subtotal = $705,466

Issue Date FY: 2024 ( Subtotal = $727,285 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	1	9/4/2024	NEW	$72,729
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	1	11/6/2023	NEW	$654,556
														Subtotal = $727,285

Grand Total All Awards = $2,160,036

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Mechanisms of White-Opaque Switching in Candida albicans

Award Number: R01AI175080

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/06/2023

PERIOD OF PERFORMANCE END DATE: 10/31/2028

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