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Development and function of skin-resident innate-like T cells at early postnatal stages

Award Number: R01AI174181
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/07/2023
PERIOD OF PERFORMANCE END DATE: 10/31/2028

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Development and function of skin-resident innate-like T cells at early postnatal stages - Summary Unlike conventional T/B lymphocytes, a group of innate-like T cells, such as γδT cells and invariant NK T (iNKT) cells, preferentially reside in epithelial tissues such as the skin where they play important roles in the first line of defense to maintain the tissue integrity and, when dysregulated, also contribute to the tissue inflammatory diseases. Understanding how skin-specific localization and maintenance of innate- like T cells are regulated is critical in helping to design strategies targeting these cells for therapeutic purposes. Our preliminary studies found that iNKT cells generated in the thymus of early postnatal stages preferentially acquire a skin-homing property for their specific distribution into the skin. Considering the skin is the outmost barrier tissue exposed to foreign environments immediately after the birth of a body, we propose that the preferential generation of the skin-homing iNKT cells in the thymus are important for protection of the “border” in the infant and young and the establishment of the local immune homeostasis. In this grant application, we will dissect mechanisms regulating thymic generation of skin-homing iNKT cells and their roles in helping skin tissue development and homeostasis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $515,435 )
2025	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Allergy and Infectious Diseases Research	001	2	11/12/2024	SUPPLEMENT FOR EXPANSION	$54,277
2025	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Allergy and Infectious Diseases Research	000	2	11/6/2024	NON-COMPETING CONTINUATION	$461,158
														Subtotal = $515,435

Issue Date FY: 2024 ( Subtotal = $492,726 )
2024	2024	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Allergy and Infectious Diseases Research	002	1	9/4/2024	NEW	$47,540
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Allergy and Infectious Diseases Research	000	1	11/7/2023	NEW	$427,881
2024	2024	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Allergy and Infectious Diseases Research	001	1	7/16/2024	SUPPLEMENT FOR EXPANSION	$17,305
														Subtotal = $492,726

Grand Total All Awards = $1,008,161

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Development and function of skin-resident innate-like T cells at early postnatal stages

Award Number: R01AI174181

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/07/2023

PERIOD OF PERFORMANCE END DATE: 10/31/2028

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