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Invasive Pneumococcal Disease and Carriage among Children with Sickle Cell Disease in Ghana: A Post-vaccination Study

Award Number: R01AI169674
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/12/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Invasive Pneumococcal Disease and Carriage among Children with Sickle Cell Disease in Ghana: A Post-vaccination Study - PROJECT SUMMARY Pneumococcal carriage is the precursor for development of pneumococcal disease, and is also responsible for transmission of the organism from person-to-person. Children with Sickle Cell Disease (SCD) are particularly susceptible to invasive pneumococcal disease (IPD) due to the i n a b i l i t y of their defective immune system to effectively handle encapsulated bacteria. This has led to the recommendation of anti-pneumococcal prophylaxis for SCD children including the administration of penicillin and the 23-valent polysaccharide vaccine (PPV23) in the past. Though these prophylactic measures decreased the rate of IPD among SCD children, breakthrough disease still occurred, mostly in children aged <3 years. In the last decade, Pneumococcal Conjugate Vaccines (PCVs) have become available in about 80% of the countries in sub-Saharan Africa. Epidemiological evidence from various studies indicate that PCVs can cause a shift in the distribution of pneumococcal serotypes usually towards non- vaccines types in both carriage and disease. In areas of high SCD prevalence in sub-Saharan Africa, pneumococcal surveillance data following introduction of PCVs remain scarce. The goal of this proposed study is to understand the epidemiology of pneumococcal carriage and invasive disease among children with SCD in the post-conjugate vaccine era in Ghana. To address this goal, we will execute three specific aims as follows: (i) to determine the frequency of pneumococci acquisition in SCD children vaccinated with PCV13 and evaluate the common serotypes carried and their persistence. (ii) to determine the incidence of IPD and the causative serotypes among children with SCD. (iii) to evaluate the antibiogram of pneumococci isolated from children with SCD and describe the penicillin and / or multidrug resistant clones. Information from the study would be useful in the prevention and management of pneumococcal infections among children with SCD in Ghana.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $123,489 )
2025	2025	UNIVERSITY OF GHANA	LEGON BOUNDARY	ACCRA				GHA	Allergy and Infectious Diseases Research	000	4	5/29/2025	NON-COMPETING CONTINUATION	$123,489
														Subtotal = $123,489

Issue Date FY: 2024 ( Subtotal = $105,754 )
2024	2024	UNIVERSITY OF GHANA	LEGON BOUNDARY	ACCRA				GHA	Allergy and Infectious Diseases Research	000	3	7/8/2024	NON-COMPETING CONTINUATION	$105,754
														Subtotal = $105,754

Issue Date FY: 2023 ( Subtotal = $125,095 )
2023	2023	UNIVERSITY OF GHANA	UNIVERSITY OF GHANA	LEGON				GHA	Allergy and Infectious Diseases Research	001	2	4/21/2023	NON-COMPETING CONTINUATION	$125,095
2023	2022	UNIVERSITY OF GHANA	UNIVERSITY OF GHANA	LEGON				GHA	Allergy and Infectious Diseases Research	000	1	1/31/2023	NEW	$0
														Subtotal = $125,095

Issue Date FY: 2022 ( Subtotal = $134,924 )
2022	2022	UNIVERSITY OF GHANA	UNIVERSITY OF GHANA	LEGON				GHA	Allergy and Infectious Diseases Research	000	1	5/12/2022	NEW	$134,924
														Subtotal = $134,924

Grand Total All Awards = $489,262

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Invasive Pneumococcal Disease and Carriage among Children with Sickle Cell Disease in Ghana: A Post-vaccination Study

Award Number: R01AI169674

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/12/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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