Wednesday, September 17, 2025 9/17/2025

Brief Longitudinal Incident Sentinel Surveillance (BLISS) to End the HIV Epidemic among Persons Who Inject Drugs (PWID)

Award Number: R01AI169635
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Brief Longitudinal Incident Sentinel Surveillance (BLISS) to End the HIV Epidemic among Persons Who Inject Drugs (PWID) - The endgame for eliminating HIV will become increasingly difficult as transmission persists among people who inject drugs (PWID). Although San Francisco appears on track to achieve zero new HIV infections within the next few years, the trajectory among PWID lags behind. The slower rate of decrease in HIV among PWID may be due to lower levels of awareness and uptake of pre-exposure prophylaxis (PrEP). Meanwhile, neighboring Alameda County (home to Oakland) has seen little decrease in the HIV epidemic with outbreaks occurring among PWID. In addition to HIV, PWID in the United States are experiencing high levels of deaths due drug overdose. To improve response efforts, data collection systems need to be more rapid and responsive. We therefore propose to create a new epidemiological data collection system for PWID in Alameda and San Francisco counties called Brief Longitudinal Incident Sentinel Surveillance (BLISS). We will recruit 600 PWID (300 each in county) using a novel venue-based / peer-referral hybrid method called Starfish Sampling to accrue a cohort and follow them longitudinally. After HIV testing and an initial questionnaire, participants will be asked to provide brief monthly updates on several key events related to health and substance use, such as changes in preventive practices or overdose experiences. Monthly data will be collected through smart phone and online technologies with in-person options as back up. Selected sentinel events will trigger “deeper dive” data collection through ecological momentary assessments (EMAs). The sample size is designed to detect low-frequency events as early warning signals and to gather sufficient longitudinal data to understand factors influencing health behaviors. BLISS data will help identify and avert outbreaks, micro-target interventions, and address unmet care and prevention needs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $235,470 )
2025	2025	CITY & COUNTY OF SAN FRANCISCO	101 GROVE ST	SAN FRANCISCO	CA	94102	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	4	8/25/2025	NON-COMPETING CONTINUATION	$235,470
														Subtotal = $235,470

Issue Date FY: 2024 ( Subtotal = $235,470 )
2024	2024	CITY & COUNTY OF SAN FRANCISCO	101 GROVE ST	SAN FRANCISCO	CA	94102	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	3	7/19/2024	NON-COMPETING CONTINUATION	$235,470
														Subtotal = $235,470

Issue Date FY: 2023 ( Subtotal = $205,679 )
2023	2023	CITY & COUNTY OF SAN FRANCISCO	101 GROVE ST	SAN FRANCISCO	CA	94102	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	2	6/23/2023	NON-COMPETING CONTINUATION	$205,679
														Subtotal = $205,679

Issue Date FY: 2022 ( Subtotal = $178,137 )
2022	2022	CITY & COUNTY OF SAN FRANCISCO	101 GROVE ST	SAN FRANCISCO	CA	94102	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	1	8/15/2022	NEW	$178,137
														Subtotal = $178,137

Grand Total All Awards = $854,756

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Brief Longitudinal Incident Sentinel Surveillance (BLISS) to End the HIV Epidemic among Persons Who Inject Drugs (PWID)

Award Number: R01AI169635

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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