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Modeling the influence of temperature on the evolution of vector-virus interactions

Award Number: R01AI168097
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/03/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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Modeling the influence of temperature on the evolution of vector-virus interactions - PROJECT SUMMARY Warmer temperatures have been associated with increased virus transmission and emergence of novel pathogens and vectors in new locations. Temperature is well documented to have a significant effect on viral fitness and replication, which is particularly relevant in ectothermic vectors of enzootic viruses such as mosquitoes. Temperature also impacts numerous aspects of invertebrate biology and therefore is a critical factor influencing the transmission potential of vector populations. Studies to date which aim to model environmental effects on population level viral dynamics assume static biological systems. Given the strong effects of temperature on viral replication rates (and consequently evolutionary rates), the variability of vector species and population responses to temperature, and the documented role of interactions among viral genotype and environment in governing transmission, this assumption is flawed. This represents a clear gap in our understanding of pathogen transmission theory and a barrier to developing accurate predictive models. West Nile virus (WNV; Flavivirus, Flaviviridae) is the most prevalent arbovirus in the U.S. and the ideal candidate for modeling how temperature and viral genotype interact to influence transmission and evolution of arboviruses in dynamic vector populations. There is large variability in prevalence in mosquitoes over both fine and broad temporal and geographic scales, and this variability has been well-documented in the U.S. Variation in temperature and viral genotypes have also been documented over similar scales. We will utilize novel laboratory data to refine predictions of arbovirus transmission under various evolutionary and climate scenarios, and ultimately to create more informed predictive models that should have broader implications for vector-borne pathogens.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $470,383 )
2025	2025	HEALTH RESEARCH, INC.	150 BROADWAY STE 280	MENANDS	NY	12204	ALBANY	USA	Allergy and Infectious Diseases Research	000	4	2/13/2025	NON-COMPETING CONTINUATION	$470,383
														Subtotal = $470,383

Issue Date FY: 2024 ( Subtotal = $488,241 )
2024	2024	HEALTH RESEARCH, INC.	150 BROADWAY STE 280	MENANDS	NY	12204	ALBANY	USA	Allergy and Infectious Diseases Research	001	3	5/29/2024	NON-COMPETING CONTINUATION	$48,823
2024	2024	HEALTH RESEARCH, INC.	150 BROADWAY STE 280	MENANDS	NY	12204	ALBANY	USA	Allergy and Infectious Diseases Research	000	3	1/16/2024	NON-COMPETING CONTINUATION	$439,418
														Subtotal = $488,241

Issue Date FY: 2023 ( Subtotal = $484,931 )
2023	2023	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	000	2	1/10/2023	NON-COMPETING CONTINUATION	$484,931
														Subtotal = $484,931

Issue Date FY: 2022 ( Subtotal = $482,931 )
2022	2022	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	000	1	2/3/2022	NEW	$482,931
														Subtotal = $482,931

Grand Total All Awards = $1,926,486

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Modeling the influence of temperature on the evolution of vector-virus interactions

Award Number: R01AI168097

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/03/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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