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RNA-binding proteins in bacterial virulence and host-pathogen interactions

Award Number: R01AI162696
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/14/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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RNA-binding proteins in bacterial virulence and host-pathogen interactions - PROJECT SUMMARY The ability of bacteria to rapidly sense and respond to changes in the environment is fundamental to colonization. Post-transcriptional regulation is emerging as an important strategy that promotes efficient and precise control of bacterial virulence, and thus plays a central role in pathogenesis. Enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a bacterial pathogen that colonizes the human colon and causes severe hemorrhagic colitis and hemolytic uremic syndrome (HUS), which can be fatal. EHEC is able to efficiently acquire nutrients and coordinate expression of traits that promote intestinal colonization, suggesting that EHEC has evolved mechanisms to spatiotemporally control virulence gene expression to occur within appropriate host niches. RNA binding proteins play important roles in bacterial gene expression by modulating transcription termination, RNA stability, and translation; however, the targets and molecular mechanisms of most RNA binding proteins and the corresponding impact on bacterial virulence and host interactions are poorly resolved. The proposed work will elucidate the regulatory mechanisms of RNA binding proteins and importance to fitness within the intestine, as well as examine how these RNA binding proteins are activated within transcriptional networks and in response to host cues.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $463,356 )
2025	2025	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	3	12/6/2024	NON-COMPETING CONTINUATION	$463,356
														Subtotal = $463,356

Issue Date FY: 2024 ( Subtotal = $477,686 )
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	2	5/20/2024	NON-COMPETING CONTINUATION	$47,768
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	2	12/7/2023	NON-COMPETING CONTINUATION	$429,918
														Subtotal = $477,686

Issue Date FY: 2023 ( Subtotal = $485,686 )
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	1	1/13/2023	NEW	$485,686
														Subtotal = $485,686

Grand Total All Awards = $1,426,728

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RNA-binding proteins in bacterial virulence and host-pathogen interactions

Award Number: R01AI162696

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/14/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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