Thursday, November 21, 2024 11/21/2024

Wells and Enteric Disease Transmission: A randomized trial of children supplied drinking water from private wells (WET-Trial)

Award Number: R01AI153376
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Approximately 48 million people in the US are served by private, and frequently untreated, wells. Our best estimate is that 1.3 million cases of gastrointestinal illnesses (GI) per year are attributed to consuming water from untreated private wells in the US, but in reality, there are no robust epidemiological data that can be used to estimate cases of GI attributable to these sources. It is likely that well water-associated GI causes significant healthcare costs and lost work/school days, as well as increased risk for long term health complications. This impact is magnified when accounting for vulnerable populations such as children under the age of 5, the elderly, and the immunocompromised. We propose the first randomized controlled trial (RCT) to estimate the burden of GI associated with private well water. We will test if household treatment of private well water by ultraviolet light (UV) vs. sham (placebo inactive UV device) decreases the incidence of GI in children under 5. At present, there are no prior RCTs or studies that have sought causal links between GI and the consumption of untreated water from private wells despite the fact that pathogens have been recovered in groundwater, including deep aquifers. Under the guidance of an interdisciplinary advisory committee we will execute the following aims: Aim 1- Quantify the incidence rate of endemic childhood GI associated with consuming untreated private well water and compare that to the incidence rate of consuming well water treated by UV. Aim 1a- Construct a Quantitative Microbial Risk Assessment (QMRA) using water quality data we collect to estimate the risk of childhood GI associated with consuming untreated private well water and compare the incidence from the risk model to the incidence we calculate in Aim 1. Aim 2- Identify, quantify and compare viral, bacterial and protozoan pathogens in stool of children consuming UV treated or untreated (sham) private well water (including both asymptomatic and symptomatic cases). Aim 3- Explore the presence of pathogens in untreated well water and stool samples of children consuming untreated private well water (sham group only). These data will fill a knowledge gap on sporadic GI associated with federally-unregulated private water supplies in the US. Our results will test an affordable water treatment intervention and inform GI burden estimates and policy decisions for managing well water in the US and globally. Policy changes will help better protect rural families, especially children who are at highest risk for sporadic enteric infections.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $346,028 )
2024	2024	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1805 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	001	5	9/20/2024	NON-COMPETING CONTINUATION	$229,699
2024	2024	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1805 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	5	8/27/2024	NON-COMPETING CONTINUATION	$116,329
														Subtotal = $346,028

Issue Date FY: 2023 ( Subtotal = $668,975 )
2023	2023	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	4	8/3/2023	NON-COMPETING CONTINUATION	$668,975
														Subtotal = $668,975

Issue Date FY: 2022 ( Subtotal = $772,757 )
2022	2022	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	3	8/24/2022	NON-COMPETING CONTINUATION	$772,757
														Subtotal = $772,757

Issue Date FY: 2021 ( Subtotal = $783,180 )
2021	2021	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	001	2	8/12/2021	NON-COMPETING CONTINUATION	$783,180
2021	2020	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	1	2/2/2021	NEW	$0
														Subtotal = $783,180

Issue Date FY: 2020 ( Subtotal = $764,813 )
2020	2020	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	1	6/22/2020	NEW	$764,813
														Subtotal = $764,813

Grand Total All Awards = $3,335,753

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Wells and Enteric Disease Transmission: A randomized trial of children supplied drinking water from private wells (WET-Trial)

Award Number: R01AI153376

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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