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Monitoring the development of resistance to the novel insecticide clothianidin in Anopheles gambiae

Award Number: R01AI150529
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Despite ongoing efforts to diversify malaria control interventions with new technologies such as the use of transgenic mosquitoes to suppress or replace wild vector populations, insecticides remain the cornerstone of strategies aimed at reducing the global burden of this disease. In sub-Saharan Africa in particular, the massive deployment of long-lasting insecticidal nets and indoor residual spraying has contributed to a significant reduction in malaria incidence in just two decades. For this reason, the development of insecticide resistance currently observed among vector populations is regarded as a very serious thread that can quickly undermine recent gains in malaria control. To preserve the effectiveness of insecticides used for malaria vector control, target interventions informed by sufficient knowledge of the susceptibility profile of local populations are more than crucial. Our project aims to study the development of resistance to clothianidin, a new insecticide recently approved for indoor residual spraying. To achieve our goal, we will capitalize on an international collaboration between Liverpool School of Topical Medicine in the UK, Centre for Research in Infectious Diseases in Cameroon as well as notional and international partners directly involved in the fight against malaria in Cameroon. This collaboration will foster capacity building and transfer of technologies in order to promote the use state- of-the-art genomic and functional genomic tools to address the underpinnings of insecticide resistance in malaria vectors in endemic countries. The specific aims of our project are: 1) to monitor the susceptibility of An. gambiae to clothianidin in Cameroon, 2) to evaluate the development and establishment of resistance in clothianidin-selected populations of An. gambiae, and 3) to determine the genetic loci underlying resistance to clothianidin. !


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $135,000 )
2024	2024	CENTRE FOR RESEARCH IN INFECTIOUS DISEASES	39 RUE MARCUS ETOUNDI	YAOUNDE				CMR	Allergy and Infectious Diseases Research	000	5	7/10/2024	NON-COMPETING CONTINUATION	$135,000
														Subtotal = $135,000

Issue Date FY: 2023 ( Subtotal = $135,000 )
2023	2023	CENTRE FOR RESEARCH IN INFECTIOUS DISEASES - CRID	39 RUE MARCUS ETOUNDI	YAOUNDE				CMR	Allergy and Infectious Diseases Research	001	4	3/30/2023	NON-COMPETING CONTINUATION	$135,000
2023	2022	CENTRE FOR RESEARCH IN INFECTIOUS DISEASES - CRID	39 RUE MARCUS ETOUNDI	YAOUNDE				CMR	Allergy and Infectious Diseases Research	000	3	1/30/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $135,000

Issue Date FY: 2022 ( Subtotal = $135,000 )
2022	2022	CENTRE FOR RESEARCH IN INFECTIOUS DISEASES - CRID	39 RUE MARCUS ETOUNDI	YAOUNDE				CMR	Allergy and Infectious Diseases Research	000	3	5/16/2022	NON-COMPETING CONTINUATION	$135,000
														Subtotal = $135,000

Issue Date FY: 2021 ( Subtotal = $135,000 )
2021	2021	CENTRE FOR RESEARCH IN INFECTIOUS DISEASES - CRID	39 RUE MARCUS ETOUNDI	YAOUNDE				CMR	Allergy and Infectious Diseases Research	000	2	5/5/2021	NON-COMPETING CONTINUATION	$135,000
														Subtotal = $135,000

Issue Date FY: 2020 ( Subtotal = $135,000 )
2020	2020	CENTRE FOR RESEARCH IN INFECTIOUS DISEASES - CRID	39 RUE MARCUS ETOUNDI	YAOUNDE				CMR	Allergy and Infectious Diseases Research	000	1	5/1/2020	NEW	$135,000
														Subtotal = $135,000

Grand Total All Awards = $675,000

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Monitoring the development of resistance to the novel insecticide clothianidin in Anopheles gambiae

Award Number: R01AI150529

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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