Understanding immunometabolism at the systemic level is important to vaccine development
and cancer immunotherapy. While new data are coming out, methodical measurements of small
molecules using metabolomics are still limited. Our team recently reported a multi-omics study
of herpes zoster vaccine (Zostavax), which identified major metabolic influences to vaccine
induced immunity, including inositol phosphate metabolism and steroid metabolism. To fully test
the metabolite predictors of immune responses, we have acquired samples from a larger
Zostavax study, and propose to perform advanced, high-coverage metabolomics analysis.
Predictive models of immune responses will be developed on one cohort and tested on the
other. These data will also be compared to a newer and more efficacious zoster vaccine.
Together, this study will establish how metabolite profiles determine the immune responses of