Thursday, August 21, 2025 8/21/2025

A targeted anti-HIV drug delivery to the GALT

Award Number: R01AI147731
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/16/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2026

Group Awards By:

View Award Description

A targeted anti-HIV drug delivery to the GALT - Human Immunodeficiency Virus 1 (HIV-1) remains one of the leading causes of death worldwide predominantly in resource-limited countries. The present Combined Antiretroviral Therapy (cART) has significantly reduced disease mortality among patients. However, the virus still persists in viral reservoir organs such as Gut-associated lymphoid tissue (GALT). Mostly cART drugs have failed to eradicate GALT reservoir because of its complex physiology. In this regard, drugs that specifically reach out to that remote lymphatic tissue at therapeutic level for an extended period of time will be of current interest. Considering the next-generation therapy for HIV-1 as one of the priority research areas of Office of AIDS Research, we propose to develop a nanomedicine based long-acting anti-HIV drug formulation targeting Microfold cells (M-cell) in the GALT. M-cells are specialized epithelial cells that are predominantly present in the gastrointestinal tract. It effectively transports many micromolecules to the underlying mucosal immune system. Considering the transcytosis property of M-cell, we have developed a pluronic nanocarrier containing three currently recommended anti-HIV drugs (also called nanodrug). This nanodrug is bio-conjugated with anti-M-cell specific antibody for targeted drug delivery to M-cell. We hypothesize that an M- cell mediated drug delivery will be more sustained and effective than conventional drugs to the GALT.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $554,550 )
2025	2025	THE UNIVERSITY OF TEXAS RIO GRANDE VALLEY	1201 W UNIVERSITY DR	EDINBURG	TX	78539	HIDALGO	USA	Allergy and Infectious Diseases Research	000	6	7/2/2025	NON-COMPETING CONTINUATION	$554,550
														Subtotal = $554,550

Issue Date FY: 2024 ( Subtotal = $561,283 )
2024	2024	THE UNIVERSITY OF TEXAS RIO GRANDE VALLEY	1201 W UNIVERSITY DR	EDINBURG	TX	78539	HIDALGO	USA	Allergy and Infectious Diseases Research	000	5	6/25/2024	NON-COMPETING CONTINUATION	$561,283
														Subtotal = $561,283

Issue Date FY: 2023 ( Subtotal = $561,283 )
2023	2023	THE UNIVERSITY OF TEXAS RIO GRANDE VALLEY	1201 W UNIVERSITY DR	EDINBURG	TX	78539	HIDALGO	USA	Allergy and Infectious Diseases Research	000	4	6/5/2023	NON-COMPETING CONTINUATION	$561,283
														Subtotal = $561,283

Issue Date FY: 2022 ( Subtotal = $314,734 )
2022	2022	UNIVERSITY OF TEXAS RIO GRANDE VALLEY, THE	1201 WEST UNIVERSITY DR	EDINBURG	TX	78539	HIDALGO	USA	Allergy and Infectious Diseases Research	000	3	8/9/2022	NON-COMPETING CONTINUATION	$314,734
														Subtotal = $314,734

Issue Date FY: 2021 ( Subtotal = $657,928 )
2021	2021	UNIVERSITY OF TEXAS RIO GRANDE VALLEY, THE	1201 WEST UNIVERSITY DR	EDINBURG	TX	78539	HIDALGO	USA	Allergy and Infectious Diseases Research	001	2	6/16/2021	NON-COMPETING CONTINUATION	$657,928
2021	2020	UNIVERSITY OF TEXAS RIO GRANDE VALLEY, THE	1201 WEST UNIVERSITY DR	EDINBURG	TX	78539	HIDALGO	USA	Allergy and Infectious Diseases Research	000	1	6/16/2021	NEW	$0
														Subtotal = $657,928

Issue Date FY: 2020 ( Subtotal = $681,811 )
2020	2020	UNIVERSITY OF TEXAS RIO GRANDE VALLEY, THE	1201 WEST UNIVERSITY DR	EDINBURG	TX	78539	HIDALGO	USA	Allergy and Infectious Diseases Research	000	1	7/16/2020	NEW	$681,811
														Subtotal = $681,811

Grand Total All Awards = $3,331,589

Top

All Categories

About

Search

Reports

Data Submission

Award Information

A targeted anti-HIV drug delivery to the GALT

Award Number: R01AI147731

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/16/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer