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Identifying determinants of HIV-1 responsible for the nanoscale distribution and dynamics of virus assembly

Award Number: R01AI138625
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary The detailed mechanisms of Human Immunodeficiency Virus Type 1 (HIV-1) assembly constitute a significant gap in our understanding of the infection cycle of this devastating pathogen. Specifically, the mechanisms by which the essential Envelope (Env) glycoprotein and structural Gag molecule efficiently coalesce to form an infectious HIV-1 particle are poorly understood, due to our inability to quantitatively measure the spatiotemporal dynamics of individual molecules at the nanoscale within infected host cells. This proposal aims to delineate the underpinnings of HIV-1 assembly on a single molecule basis and in a native cellular context. To accomplish these aims, we propose to utilize superresolution microscopy to visualize and quantify the stages of virus assembly in order to determine the role of key peptide motifs found in HIV-1 Env and Gag. Our preliminary data and analytics demonstrate our ability to quantitatively map the biogenesis of HIV-1 and strongly suggest that this approach will provide unequivocal insight in the mechanisms of particle assembly. These discoveries will provide new quantitative models to guide approaches aimed at thwarting HIV-1 assembly.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Allergy and Infectious Diseases Research	000	5	8/10/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $369,367 )
2022	2022	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Allergy and Infectious Diseases Research	000	5	4/26/2022	NON-COMPETING CONTINUATION	$354,458
2022	2022	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Allergy and Infectious Diseases Research	001	5	4/27/2022	SUPPLEMENT FOR EXPANSION	$14,909
														Subtotal = $369,367

Issue Date FY: 2021 ( Subtotal = $416,054 )
2021	2021	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Allergy and Infectious Diseases Research	000	4	4/12/2021	NON-COMPETING CONTINUATION	$416,054
														Subtotal = $416,054

Issue Date FY: 2020 ( Subtotal = $398,882 )
2020	2020	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Allergy and Infectious Diseases Research	000	3	3/27/2020	NON-COMPETING CONTINUATION	$354,154
2020	2020	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Allergy and Infectious Diseases Research	001	3	8/7/2020	SUPPLEMENT FOR EXPANSION	$44,728
														Subtotal = $398,882

Issue Date FY: 2019 ( Subtotal = $351,619 )
2019	2019	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Allergy and Infectious Diseases Research	000	2	4/23/2019	NON-COMPETING CONTINUATION	$351,619
														Subtotal = $351,619

Issue Date FY: 2018 ( Subtotal = $349,084 )
2018	2018	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Allergy and Infectious Diseases Research	000	1	5/9/2018	NEW	$349,084
														Subtotal = $349,084

Grand Total All Awards = $1,885,006

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Identifying determinants of HIV-1 responsible for the nanoscale distribution and dynamics of virus assembly

Award Number: R01AI138625

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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