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Impacts of Urbanization on Vector Biology and Transmission of Dengue in China

Award Number: R01AI136850
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2010
PERIOD OF PERFORMANCE END DATE: 05/31/2023

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Impacts of Urbanization on Vector Biology and Transmission of Dengue in China - Project Summary Title: Impacts of Urbanization on Vector Biology and Transmission of Dengue in China Dengue fever is an acute infectious disease caused by the dengue virus and transmitted by Aedes mosquitoes. Despite the intense control program in China, major dengue outbreaks have recently occurred in the urban area of Southern China. Control of mosquito populations is the only available strategy for prevention of dengue because there are no effective drugs for dengue. The use of chemical insecticides represents the most important element of vector control for dengue in China and worldwide. Our preliminary data indicates a rapid rise of pyrethroid resistance in the dengue vectors in urban areas of southern China. This competing renewal application will test the central hypothesis that frequent dengue outbreaks and intensive insecticide use in the urban environment lead to an emergence and spread of insecticide resistance in the dengue vector, which in turn increases vector population density and vectorial capacity for dengue. We proposed three interlinked specific aims: 1) to determine resistance level of dengue vector populations in urban and rural environments, 2) to develop new molecular tools for insecticide resistance surveillance through a better understanding of resistance mechanisms, and to conduct molecular surveillance of insecticide resistance in urban and rural environments, and 3) to determine the effect of insecticide resistance on mosquito survivorship, vector competence and vectorial capacity in urban and rural environments. We will focus on Aedes albopictus, a highly invasive species and the most important dengue vector in Southern China. The knowledge and tools from this project will help in guiding the selection of insecticides for dengue vector control, facilitate insecticide resistance surveillance and management, and enhance our understanding of dengue epidemiology in the urban environment where insecticide resistance is rapidly increasing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $132,912 )
2022	2022	SOUTHERN MEDICAL UNIVERSITY	NO.-1063, NO.1023, SHATAI S. ROAD	GUANGZHOU	GUANGDONG			CHN	Allergy and Infectious Diseases Research	000	9	5/13/2022	NON-COMPETING CONTINUATION	$132,912
														Subtotal = $132,912

Issue Date FY: 2021 ( Subtotal = $132,912 )
2021	2021	SOUTHERN MEDICAL UNIVERSITY	NO.-1063, NO.1023, SHATAI S. ROAD	GUANGZHOU	GUANGDONG			CHN	Allergy and Infectious Diseases Research	000	8	6/30/2021	NON-COMPETING CONTINUATION	$132,912
														Subtotal = $132,912

Issue Date FY: 2020 ( Subtotal = $132,912 )
2020	2020	SOUTHERN MEDICAL UNIVERSITY	NO.1023, SHATAI (S) RD., BAIYUN DISTRICT	GUANGDONG	GUANGDONG	510515		CHN	Allergy and Infectious Diseases Research	000	7	5/26/2020	NON-COMPETING CONTINUATION	$132,912
														Subtotal = $132,912

Issue Date FY: 2019 ( Subtotal = $132,911 )
2019	2019	SOUTHERN MEDICAL UNIVERSITY	NO.1023, SHATAI (S) RD., BAIYUN DISTRICT	GUANGDONG	GUANGDONG	510515		CHN	Allergy and Infectious Diseases Research	000	6	3/26/2019	NON-COMPETING CONTINUATION	$132,911
														Subtotal = $132,911

Issue Date FY: 2018 ( Subtotal = $134,909 )
2018	2018	SOUTHERN MEDICAL UNIVERSITY	NO.1023, SHATAI (S) RD., BAIYUN DISTRICT	GUANGDONG	GUANGDONG	510515		CHN	Allergy and Infectious Diseases Research	000	5	6/28/2018	COMPETING CONTINUATION	$134,909
														Subtotal = $134,909

Grand Total All Awards = $666,556

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Impacts of Urbanization on Vector Biology and Transmission of Dengue in China

Award Number: R01AI136850

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2010

PERIOD OF PERFORMANCE END DATE: 05/31/2023

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