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Microneedles for treatment of peanut allergy

Award Number: R01AI135197
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2018
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Microneedles for treatment of peanut allergy - Microneedles for treatment of peanut allergy Peanut allergy is a life-threatening condition. About 1% of the US population (~3 million people) has peanut allergies, and there is no FDA-approved treatment. Strict avoidance, and a peanut-free diet is the only option available to manage peanut allergies, which imposes severe limitations on the lifestyle of the patient and their families, and can lead to nutritional deficiencies. The overall goal of this proposal is to develop a coated microneedles (MNs) based cutaneous immunotherapy (CIT) a.k.a (MNs-CIT) for peanut allergy. Presently peanut oral immunotherapy has received much attention. However, a major limitation of oral immunotherapy is that the peanut oral dose is escalated to thousands of milligrams, which causes adverse effects. Based on our preliminary data our hypothesis is that MNs coated with peanut allergen can safely deliver peanut allergen in to the superficial skin-layer to produce long-lasting peanut desensitization. Our specific aims are: (i) Develop PE- coated MNs and evaluate their short and long term therapeutic effectiveness in treating peanut allergy, (ii) Characterize the mechanism of peanut MNs-CIT, and (iii) Evaluate therapeutic efficacy in a neonatal pig model of peanut allergy. If successful, these studies will provide the foundation to support the development of a novel and safer peanut allergy immunotherapy treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$11,372 )
2026	2022	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Allergy and Infectious Diseases Research	000	5	1/22/2026	NON-COMPETING CONTINUATION	-$11,372
														Subtotal = -$11,372

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Allergy and Infectious Diseases Research	000	5	8/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $632,712 )
2022	2022	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Allergy and Infectious Diseases Research	000	5	8/19/2022	NON-COMPETING CONTINUATION	$632,712
														Subtotal = $632,712

Issue Date FY: 2021 ( Subtotal = $649,847 )
2021	2021	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Allergy and Infectious Diseases Research	000	4	8/18/2021	NON-COMPETING CONTINUATION	$649,847
														Subtotal = $649,847

Issue Date FY: 2020 ( Subtotal = $656,540 )
2020	2020	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Allergy and Infectious Diseases Research	000	3	7/17/2020	NON-COMPETING CONTINUATION	$656,540
														Subtotal = $656,540

Issue Date FY: 2019 ( Subtotal = $656,407 )
2019	2019	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Allergy and Infectious Diseases Research	000	2	8/9/2019	NON-COMPETING CONTINUATION	$656,407
														Subtotal = $656,407

Issue Date FY: 2018 ( Subtotal = $718,524 )
2018	2018	TEXAS TECH UNIVERSITY SYSTEM	2500 BROADWAY	LUBBOCK	TX	79409	LUBBOCK	USA	Allergy and Infectious Diseases Research	000	1	9/14/2018	NEW	$718,524
														Subtotal = $718,524

Grand Total All Awards = $3,302,658

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Microneedles for treatment of peanut allergy

Award Number: R01AI135197

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2018

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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