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Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic Data

Award Number: R01AI128775
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2017
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic Data - PROJECT SUMMARY The Human Leukocyte Antigen (HLA) region on human chromosome 6p21 is the most medically important region of the human genome. Over 100 infectious, autoimmune and pharmacological disease phenotypes and cancers are associated with genetic variation of HLA, and matching of HLA genotypes is required for bone marrow and solid organ transplantation. HLA molecules have functional interactions with Killer cell Immunoglobulin-like Receptor (KIR) molecules, also recognized to play critical roles in transplantation and disease. The genes encoding these molecules are highly polymorphic and display extensive structural variation relative to other genomic regions. Recognizing the need to consolidate complex data from a broad field, in the prior project periods we developed a suite of tools and programs for the standardized analysis, collection, exchange and storage (ACES) of all current and future immunogenomic data. These tools serve to fill gaps in genomic data- management and analysis tools, which are primarily designed for use with single nucleotide polymorphism (SNP) and whole-genome and whole-exome sequence (WG/ES) data, and do not support the highly polymorphic genetic data characterized by the immunogenomic loci and other highly polymorphic genetic systems. Our standards and tools have been widely adopted by the immunogenomics community, but there remains an urgent and unmet need for integrated, easy-to use, clinical-grade tools that unify immunogenomic genotype, SNP and WG/ES data, while anticipating future genomic data formats. In the previous project periods, we have made substantial progress on the development of these tools and resources, which are designed to maximize the ongoing utility of immunogenomic data for clinical and basic research science. In the proposed project period, we will advance the development of these tools, expanding their scope and improving ease of use, centralizing their availability and enabling interoperability with electronic medical record (EMR) systems, and making them available adjacent to these highly complex datasets for application in translational medicine. We will expand the utility of our tools and services to accommodate additional data types and analytical methods, as well as integrating across methods. Building on our development of an infrastructure to support transmission of HLA data using HL7 FHIR resources, we will work to incorporate these resources into our data management tools and pipeline. Finally, we will build on an infrastructure developed to support aggregation and standardized analysis of HLA data in the context of COVID-19 to support additional data types and disease phenotypes for immunogenomic disease association studies. By integrating these resources, and other tools and services we have developed, and empowering them to generate FHIR messages, the products of these immunogenomic ACES resources can be made available and accessible to researchers and within health systems, improving our understanding of immunogenomics in human health and facilitating application for translational medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $449,783 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	13	1/30/2026	NON-COMPETING CONTINUATION	$449,783
														Subtotal = $449,783

Issue Date FY: 2025 ( Subtotal = $449,783 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	12	5/2/2025	NON-COMPETING CONTINUATION	$449,783
														Subtotal = $449,783

Issue Date FY: 2024 ( Subtotal = $449,783 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	11	5/29/2024	NON-COMPETING CONTINUATION	$44,979
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	11	2/26/2024	NON-COMPETING CONTINUATION	$404,804
														Subtotal = $449,783

Issue Date FY: 2023 ( Subtotal = $449,783 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	10	2/7/2023	NON-COMPETING CONTINUATION	$449,783
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	9	6/9/2023	COMPETING CONTINUATION	$139,478
2023	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	8	6/9/2023	NON-COMPETING CONTINUATION	-$139,478
2023	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	7	5/17/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $449,783

Issue Date FY: 2022 ( Subtotal = $495,908 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	9	1/20/2022	COMPETING CONTINUATION	$495,908
														Subtotal = $495,908

Issue Date FY: 2021 ( Subtotal = $377,400 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	8	2/22/2021	NON-COMPETING CONTINUATION	$377,400
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	7	5/7/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $377,400

Issue Date FY: 2020 ( Subtotal = $633,739 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	7	2/20/2020	NON-COMPETING CONTINUATION	$377,400
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	7	5/13/2020	SUPPLEMENT FOR EXPANSION	$256,339
														Subtotal = $633,739

Issue Date FY: 2019 ( Subtotal = $377,400 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	6	3/6/2019	NON-COMPETING CONTINUATION	$377,400
														Subtotal = $377,400

Issue Date FY: 2018 ( Subtotal = $377,400 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	5	2/5/2018	NON-COMPETING CONTINUATION	$377,400
														Subtotal = $377,400

Issue Date FY: 2017 ( Subtotal = $435,900 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	4	1/13/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$435,900
														Subtotal = $435,900

Grand Total All Awards = $4,496,879

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Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic Data

Award Number: R01AI128775

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2017

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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