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HIGH-THROUGHPUT EPITOPE DISCOVERY: USE OF NEXT-GENERATION PEPTIDE CHIPS FOR FAST IDENTIFICATION AND FINE MAPPING OF DIAGNOSTIC AND PROGNOSTIC MARKERS FOR CHAGAS DISEASE

Award Number: R01AI123070
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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¿ DESCRIPTION (provided by applicant): Trypanosoma cruzi is a parasite responsible for an important human disease, Chagas Disease, which is endemic in the Americas. The parasite is transmitted by the bite of an insect, or by blood transfusion or organ transplants. The current drugs available for treatment are able to cure the disease in its acute phase, and provide benefits to patients in the chronic stage, but certification of cure is difficult to achieve. Management and surveillance of this disease rests heavily on the use of diagnostic tools, which are based on the detection of circulating antibodies against parasite proteins or protein fragments. However, in spite of the availability of a few diagnostic tests for screening blood banks, and for diagnosing the disease, there are major unmet needs in this area. There are currently no biomarkers that can differentially diagnose infections by different parasite strains (which could be linked to drug sensitivity and disease prognosis). Also, there are no tests that provide an early indication of therapeutic treatment success or failure, which constitutes a major obstacle in current drug trials. A constant stream of new biomarkers is required to explore their potential to develop new diagnostic tools. One of the most promising developments in recent years is the ability to produce high-density peptide microarrays, which allow the production of tiling displays of essentially complete pathogen proteomes. The goal of this application is to study the complexity of the human antibody response against this parasite, and to identify thousands of novel serology markers for further characterization. Using high-density peptide microarrays covering the complete Trypanosoma cruzi proteome we will screen sera from diverse Chagas Disease patient populations to identify all antibody- binding protein fragments recognized by these immune responses. This will provide a comprehensive set of novel biomarkers. We will complement this strategy with two comparative studies in which we will seek to define biomarkers that i) are able to differentiate infection by different parasite lineage, and ii) are able to predict treatment success/failure. These studies will feed a pipeline of downstream experiments which will validate these biomarkers for the development of new diagnostic tools.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	FUNDACION INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS	COLECTORA DE AVENIDA GENERAL PAZ 5445	SAN MARTIN	BUENOS AIRES			ARG	Allergy and Infectious Diseases Research	001	5	5/15/2023	NON-COMPETING CONTINUATION	$0
2023	2020	FUNDACION INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS	COLECTORA DE AVENIDA GENERAL PAZ 5445	SAN MARTIN	BUENOS AIRES			ARG	Allergy and Infectious Diseases Research	000	5	5/4/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $106,110 )
2020	2020	FUNDACION INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS	COLECTORA DE AVENIDA GENERAL PAZ 5445, EDIFICIO 24, CC 30	SAN MARTIN	BUENOS AIRES	B1650KNA		ARG	Allergy and Infectious Diseases Research	000	5	3/2/2020	NON-COMPETING CONTINUATION	$106,110
														Subtotal = $106,110

Issue Date FY: 2019 ( Subtotal = $120,150 )
2019	2019	FUNDACION INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS	COLECTORA DE AVENIDA GENERAL PAZ 5445, EDIFICIO 24, CC 30	SAN MARTIN	BUENOS AIRES	B1650KNA		ARG	Allergy and Infectious Diseases Research	000	4	3/4/2019	NON-COMPETING CONTINUATION	$120,150
														Subtotal = $120,150

Issue Date FY: 2018 ( Subtotal = $120,150 )
2018	2018	FUNDACION INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS	COLECTORA DE AVENIDA GENERAL PAZ 5445, EDIFICIO 24, CC 30	SAN MARTIN	BUENOS AIRES	B1650KNA		ARG	Allergy and Infectious Diseases Research	000	3	2/26/2018	NON-COMPETING CONTINUATION	$120,150
														Subtotal = $120,150

Issue Date FY: 2017 ( Subtotal = $132,710 )
2017	2017	FUNDACION INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS	COLECTORA DE AVENIDA GENERAL PAZ 5445, EDIFICIO 24, CC 30	SAN MARTIN	BUENOS AIRES	B1650KNA		ARG	Allergy and Infectious Diseases Research	000	2	2/27/2017	NON-COMPETING CONTINUATION	$132,710
														Subtotal = $132,710

Issue Date FY: 2016 ( Subtotal = $132,070 )
2016	2016	INSTITUTE FOR RESEARCH IN BIOTECHNOLOGY FOUNDATION	Colectora de Avenida General Paz 54	San Martin				ARG	Allergy and Infectious Diseases Research	000	1	3/15/2016	NEW	$132,070
														Subtotal = $132,070

Grand Total All Awards = $611,190

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HIGH-THROUGHPUT EPITOPE DISCOVERY: USE OF NEXT-GENERATION PEPTIDE CHIPS FOR FAST IDENTIFICATION AND FINE MAPPING OF DIAGNOSTIC AND PROGNOSTIC MARKERS FOR CHAGAS DISEASE

Award Number: R01AI123070

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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