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Comparative incidence and clinical spectrum of Plasmodium knowlesi malaria, a longitudinal study in Sabah, Malaysia

Award Number: R01AI116472
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/10/2015
PERIOD OF PERFORMANCE END DATE: 03/31/2021

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Comparative incidence and clinical spectrum of Plasmodium knowlesi malaria, a longitudinal study in Sabah, Malaysia - ¿ DESCRIPTION (provided by applicant): Comparative incidence and clinical spectrum of Plasmodium knowlesi malaria, a longitudinal study in Sabah, Malaysia has one of the most successful malaria control programs in Southeast Asia, with marked reductions in the incidence of Plasmodium falciparum and P. vivax over recent decades and an aim to eliminate these species by 2020. However, the simian parasite P. knowlesi has emerged as a major cause of human malaria, and we recently reported that in Sabah, east Malaysia, combined notifications of P. knowlesi and the microscopically near-identical P. malariae increased >10-fold between 2004 - 2011. However, microscopic diagnosis of P. knowlesi is known to be problematic, and definitive diagnosis requires molecular methods. Hence, whether the apparent increase in P. knowlesi is due to increased recognition of the species remains uncertain, and the true incidence and trend of knowlesi malaria in Sabah, in comparison to the other human malaria species, has not been determined. P. knowlesi has a 24-hour replication cycle and can result in high parasitemias with consequent complications. Risk of severe disease appears higher than that of falciparum malaria, and fatal cases have been reported. However, many knowledge gaps remain with regards to the epidemiology and clinical features of knowlesi malaria. Large prospective longitudinal studies have not been conducted, and no prospective study has evaluated the clinical features of knowlesi malaria in children, or the occurrence and consequences of knowlesi malaria in pregnancy. In our proposed study we aim to determine the true incidence and trend of knowlesi malaria in Sabah, in comparison to the other human malaria species. This will be achieved through collaboration with the Sabah Public Health Laboratory, and will involve the implementation of state-wide molecular testing of every case of microscopy-diagnosed malaria in Sabah during the 5-year study period. Basic demographic details including pregnancy status will be recorded for all cases. Our second aim is to determine the epidemiology and clinical spectrum of knowlesi malaria at two district hospitals, including changes over time. This will be achieved through the enrolment of every patient admitted with malaria at two district hospitals in northeast Sabah, with detailed epidemiological and clinical details recorded. Our proposed research will provide for the first time accurate information regarding the true incidence of knowlesi malaria in Sabah, and the trend of this species over time in comparison to the other human malaria species. This will inform malaria control programs in Sabah, in addition to informing other countries in Southeast Asia about the potential emergence of knowlesi malaria as P. falciparum and P. vivax are brought under control. In addition, our prospective district-hospital studies will provide crucial information regarding the clinical features of knowlesi malaria in populations that have not been previously well-studied, including children and pregnant women.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	INFECTIOUS DISEASE SOCIETY KOTA KINABALU SABAH	LOCKED BAG 2029 INFECTIOUS DISEASE UNIT	KOTA KINABALU	SABAH			MYS	Allergy and Infectious Diseases Research	001	5	9/16/2021	NON-COMPETING CONTINUATION	$0
2021	2019	INFECTIOUS DISEASE SOCIETY KOTA KINABALU SABAH	LOCKED BAG 2029 INFECTIOUS DISEASE UNIT	KOTA KINABALU	SABAH			MYS	Allergy and Infectious Diseases Research	000	5	9/9/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $135,272 )
2019	2019	INFECTIOUS DISEASE SOCIETY KOTA KINABALU SABAH	INFECTIOUS DISEASE CLINIC, HOSPITAL QUEEN ELIZABETH	KOTA KINABALU	SABAH	88586		MYS	Allergy and Infectious Diseases Research	000	5	4/1/2019	NON-COMPETING CONTINUATION	$135,272
														Subtotal = $135,272

Issue Date FY: 2018 ( Subtotal = $136,728 )
2018	2018	INFECTIOUS DISEASE SOCIETY KOTA KINABALU SABAH	INFECTIOUS DISEASE CLINIC, HOSPITAL QUEEN ELIZABETH	KOTA KINABALU	SABAH	88586		MYS	Allergy and Infectious Diseases Research	000	4	3/23/2018	NON-COMPETING CONTINUATION	$136,728
														Subtotal = $136,728

Issue Date FY: 2017 ( Subtotal = $136,728 )
2017	2017	INFECTIOUS DISEASE SOCIETY KOTA KINABALU SABAH	INFECTIOUS DISEASE CLINIC, HOSPITAL QUEEN ELIZABETH	KOTA KINABALU	SABAH	88586		MYS	Allergy and Infectious Diseases Research	000	3	4/13/2017	NON-COMPETING CONTINUATION	$136,728
														Subtotal = $136,728

Issue Date FY: 2016 ( Subtotal = $136,728 )
2016	2016	INFECTIOUS DISEASE SOCIETY KOTA KINABALU SABAH	INFECTIOUS DISEASE UNIT HOSP	KOTA KINABALU, SABAH 88586				MYS	Allergy and Infectious Diseases Research	000	2	3/28/2016	NON-COMPETING CONTINUATION	$136,728
														Subtotal = $136,728

Issue Date FY: 2015 ( Subtotal = $136,728 )
2015	2015	INFECTIOUS DISEASE SOCIETY KOTA KINABALU SABAH	INFECTIOUS DISEASE UNIT HOSP	KOTA KINABALU, SABAH 88586				MYS	Allergy and Infectious Diseases Research	000	1	4/9/2015	NEW	$136,728
														Subtotal = $136,728

Grand Total All Awards = $682,184

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Comparative incidence and clinical spectrum of Plasmodium knowlesi malaria, a longitudinal study in Sabah, Malaysia

Award Number: R01AI116472

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/10/2015

PERIOD OF PERFORMANCE END DATE: 03/31/2021

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