Tuesday, February 17, 2026 2/17/2026

var gene regulation mechanisms in Malaria parasite Plasmodium falciparum

Award Number: R01AI116466
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2015
PERIOD OF PERFORMANCE END DATE: 02/29/2020

Group Awards By:

View Award Description

var gene regulation mechanisms in Malaria parasite Plasmodium falciparum - DESCRIPTION (provided by applicant): With improved financial and technical supports, many malaria endemic nations are once again considering malaria elimination as their national goal of malaria control. To achieve this ambitious goal, one of the greatest challenges is development of blood stage vaccines. Antigenic variation of PfEMP1 encoded by a 60-member var gene family and clonally expressed on the surface of Plasmodium falciparum-infected red blood cells is a critical virulence factor for malaria. Despite its central role in malaria pathogenesis during the asexual blood stage, the mechanism of mutually exclusive expression of var genes is still poorly understood, and this knowledge gap severely hinders the development of novel tools to kill blood stage parasites. This project, built on our recent success in creating a P. falciparum line with expression of all the var genes, aims to determine the molecular regulatory network and establish the hierarchy of var gene regulation mechanisms employing a set of recently developed genetic and epigenetic tools and resources. A comprehensive picture of var gene regulatory factors generated from this study will enable a better understanding of antigenic variation of the var gene family in immune evasion of malaria parasites. This information will also provide new targets for therapeutics to block PfEMP1-mediated immune evasion or complications of severe malaria, or enhance the ability of vaccines to maximize PfEMP1 expression for immune response.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES	LIFE SCIENCE RESEARCH BUILDING, NO.320, YUEYANG ROAD, XUHUI DISTRICT	SHANGHAI	SHANGHAI	200031		CHN	Allergy and Infectious Diseases Research	000	5	7/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $129,657 )
2019	2019	INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES	LIFE SCIENCE RESEARCH BUILDING, NO.320, YUEYANG ROAD, XUHUI DISTRICT	SHANGHAI	SHANGHAI	200031		CHN	Allergy and Infectious Diseases Research	000	5	3/13/2019	NON-COMPETING CONTINUATION	$129,657
														Subtotal = $129,657

Issue Date FY: 2018 ( Subtotal = $129,657 )
2018	2018	INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES	LIFE SCIENCE RESEARCH BUILDING, NO.320, YUEYANG ROAD, XUHUI DISTRICT	SHANGHAI	SHANGHAI	200031		CHN	Allergy and Infectious Diseases Research	000	4	2/26/2018	NON-COMPETING CONTINUATION	$129,657
														Subtotal = $129,657

Issue Date FY: 2017 ( Subtotal = $129,657 )
2017	2017	INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES	LIFE SCIENCE RESEARCH BUILDING, NO.320, YUEYANG ROAD, XUHUI DISTRICT	SHANGHAI	SHANGHAI	200031		CHN	Allergy and Infectious Diseases Research	000	3	3/8/2017	NON-COMPETING CONTINUATION	$129,657
														Subtotal = $129,657

Issue Date FY: 2016 ( Subtotal = $129,657 )
2016	2016	INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCI	LIFE SCIENCES RESEARCH BLDG	SHANGHAI				CHN	Allergy and Infectious Diseases Research	000	2	2/18/2016	NON-COMPETING CONTINUATION	$129,657
														Subtotal = $129,657

Issue Date FY: 2015 ( Subtotal = $129,657 )
2015	2015	INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCI	LIFE SCIENCES RESEARCH BLDG	SHANGHAI				CHN	Allergy and Infectious Diseases Research	000	1	2/28/2015	NEW	$129,657
														Subtotal = $129,657

Grand Total All Awards = $648,285

Top

All Categories

About

Search

Reports

Data Submission

Award Information

var gene regulation mechanisms in Malaria parasite Plasmodium falciparum

Award Number: R01AI116466

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2015

PERIOD OF PERFORMANCE END DATE: 02/29/2020

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer