Friday, June 20, 2025 6/20/2025

Modeling the impact and cost-effectiveness of next-generation rotavirus vaccine strategies in low- and middle-income countries

Award Number: R01AI112970
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2015
PERIOD OF PERFORMANCE END DATE: 08/31/2025

Group Awards By:

View Award Description

Modeling the impact and cost-effectiveness of next-generation rotavirus vaccine strategies in low- and middle-income countries - PROJECT SUMMARY/ABSTRACT Despite the introduction of live oral rotavirus vaccines into more than 90 countries worldwide, rotavirus remains a leading cause of severe diarrhea in children and a major source of morbidity and mortality in low- and middle-income countries (LMICs). Rotavirus vaccination has been effective at controlling the burden of rotavirus-associated gastroenteritis (RVGE) in high-income countries, but the response, efficacy, and impact of current live oral rotavirus vaccines is lower in LMICs for multiple reasons that are still not fully understood. New vaccines and approaches may be needed to overcome the poor immune response to current live oral rotavirus vaccines in LMICs. Next-generation rotavirus vaccines, including neonatal and parenteral subunit vaccines, are currently in development and undergoing clinical trials at our field sites in Malawi and Ghana. Models are needed to extrapolate the results of these trials to the population level. We will use mathematical models to predict the potential impact of different rotavirus vaccination strategies, accounting for both the direct and indirect effects of vaccination. We will then conduct economic evaluations to determine the most cost-effective approach to reducing the burden of diarrhea due to rotavirus. We will begin by focusing on Malawi and Ghana, where we have previously developed models and have good pre- and post-vaccination surveillance data. We will then extend our approach to predict vaccine impact and cost-effectiveness across all LMICs. Our analyses will help to better define the vaccine response, duration of immunity, and price at which next-generation rotavirus vaccines are likely to be cost-effective, and will provide a validated platform that decision-makers in LMICs can use to weigh the costs and benefits of different rotavirus vaccination strategies in their country.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $422,491 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	10	8/13/2024	NON-COMPETING CONTINUATION	$422,491
														Subtotal = $422,491

Issue Date FY: 2023 ( Subtotal = $425,285 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	9	8/29/2023	NON-COMPETING CONTINUATION	$425,285
														Subtotal = $425,285

Issue Date FY: 2022 ( Subtotal = $426,512 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	002	8	8/26/2022	NON-COMPETING CONTINUATION	$426,512
2022	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	001	6	11/11/2021	COMPETING CONTINUATION	$119,628
2022	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	5	11/11/2021	NON-COMPETING CONTINUATION	-$119,628
														Subtotal = $426,512

Issue Date FY: 2021 ( Subtotal = $426,382 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	7	8/12/2021	NON-COMPETING CONTINUATION	$426,382
														Subtotal = $426,382

Issue Date FY: 2020 ( Subtotal = $480,377 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	001	6	9/17/2020	COMPETING CONTINUATION	$480,377
2020	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	5	9/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $480,377

Issue Date FY: 2019 ( Subtotal = $371,943 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	5	1/11/2019	NON-COMPETING CONTINUATION	$371,943
														Subtotal = $371,943

Issue Date FY: 2018 ( Subtotal = $372,036 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	4	1/20/2018	NON-COMPETING CONTINUATION	$372,036
														Subtotal = $372,036

Issue Date FY: 2017 ( Subtotal = $372,239 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	3	1/27/2017	NON-COMPETING CONTINUATION	$372,239
														Subtotal = $372,239

Issue Date FY: 2016 ( Subtotal = $372,453 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	2	1/26/2016	NON-COMPETING CONTINUATION	$372,453
														Subtotal = $372,453

Issue Date FY: 2015 ( Subtotal = $404,745 )
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Allergy and Infectious Diseases Research	000	1	1/29/2015	NEW	$404,745
														Subtotal = $404,745

Grand Total All Awards = $4,074,463

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Modeling the impact and cost-effectiveness of next-generation rotavirus vaccine strategies in low- and middle-income countries

Award Number: R01AI112970

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2015

PERIOD OF PERFORMANCE END DATE: 08/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer