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Monitoring SIV Reservoirs with Whole Body immunoPET

Award Number: R01AI111907
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2014
PERIOD OF PERFORMANCE END DATE: 06/30/2020

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Monitoring SIV Reservoirs with Whole Body immunoPET - DESCRIPTION (provided by applicant): With the advent of novel anti-retroviral therapies, the prospect of potentially eliminating HIV from infected patients may become an achievable goal. However, such goal will require new tools with greater sensitivity than currently available to monitor the progress of such therapy, no only in blood but also in organs that do harbor such reservoirs and sites of residual viral replication in vivo. In addition, identifying early seeding of viral reservoirs during acute infecton relative to the route of transmission and disease progression may open novel directions for chemotherapeutic or immune barriers to contain the new virus infection foyers and generalized dissemination of the infection with seeding of viral reservoirs. To harness such early viral dynamics and account for the natural individual variation that exists for such dynamics, there is a need to understand the dissemination patterns of HIV infection following mucosal transmission, the primary transmission mode of infection worldwide. However, the tools currently available to monitor such viral processes are either indirect or relatively invasive and clearly impractical for the human clinic. Even when one uses the nonhuman primate model of AIDS, understanding the viral dynamics in real time is challenging and prohibitively expensive if one chooses to perform serial sacrifices, not to mention fraught by a high degree of variability between individuals. In this project, we propose to optimize our established immuno-positron emission tomography (PET) with simultaneous X-ray computed tomography (CT), to determine real-time whole body maps of simian immunodeficiency virus replication sites in vivo to chart out the total body replication sites of SIV in vivo and determine viral dynamics and sites of residual viral replication during antiretroviral therapy. Thus we propose to determine the anatomic SIV viral dynamics following infection via the IV, rectal and vaginal route to determine the consecutive major sites of viral replication in vivo, which will be confirmed via targeted tissue collections. Next we will compare 2 combination ART therapies for reducing viral reservoirs and document residual foyers of replication in vivo as well as determine which such reservoirs might be fueling the viral resurgence after interruption of ART in vivo. We submit that these studies wil provide critical information for the design of HIV eradication strategies in human HIV infection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2018	UNIVERSITY OF LOUISIANA AT LAFAYETTE	104 E UNIVERSITY CIR 3RD FL	LAFAYETTE	LA	70503	LAFAYETTE	USA	Allergy and Infectious Diseases Research	000	6	9/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = -$616,472 )
2021	2018	UNIVERSITY OF LOUISIANA AT LAFAYETTE	104 E UNIVERSITY CIR 3RD FL	LAFAYETTE	LA	70503	LAFAYETTE	USA	Allergy and Infectious Diseases Research	000	6	4/29/2021	NON-COMPETING CONTINUATION	-$616,472
														Subtotal = -$616,472

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	UNIVERSITY OF LOUISIANA AT LAFAYETTE	104 E UNIVERSITY CIR 3RD FL	LAFAYETTE	LA	70503	LAFAYETTE	USA	Allergy and Infectious Diseases Research	000	6	7/16/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $1,056,530 )
2018	2018	UNIVERSITY OF LOUISIANA AT LAFAYETTE	104 E UNIVERSITY CIR 3RD FL	LAFAYETTE	LA	70503	LAFAYETTE	USA	Allergy and Infectious Diseases Research	000	6	6/29/2018	NON-COMPETING CONTINUATION	$1,056,530
														Subtotal = $1,056,530

Issue Date FY: 2017 ( Subtotal = $1,590,807 )
2017	2017	UNIVERSITY OF LOUISIANA AT LAFAYETTE	104 E UNIVERSITY CIR 3RD FL	LAFAYETTE	LA	70503	LAFAYETTE	USA	Allergy and Infectious Diseases Research	001	5	6/20/2017	NON-COMPETING CONTINUATION	$535,000
2017	2017	UNIVERSITY OF LOUISIANA AT LAFAYETTE	104 E UNIVERSITY CIR 3RD FL	LAFAYETTE	LA	70503	LAFAYETTE	USA	Allergy and Infectious Diseases Research	000	5	6/14/2017	NON-COMPETING CONTINUATION	$1,055,807
														Subtotal = $1,590,807

Issue Date FY: 2016 ( Subtotal = $1,039,392 )
2016	2016	UNIVERSITY OF LOUISIANA AT LAFAYETTE	P.O. BOX 43610	LAFAYETTE	LA	70503	LAFAYETTE	USA	Allergy and Infectious Diseases Research	002	4	6/20/2016	NON-COMPETING CONTINUATION	$1,043,190
2016	2015	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	2	12/8/2015	NON-COMPETING CONTINUATION	-$734,707
2016	2015	UNIVERSITY OF LOUISIANA AT LAFAYETTE	P.O. BOX 43610	LAFAYETTE	LA	70503	LAFAYETTE	USA	Allergy and Infectious Diseases Research	001	3	12/8/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$730,909
														Subtotal = $1,039,392

Issue Date FY: 2015 ( Subtotal = $1,101,479 )
2015	2015	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	2	6/11/2015	NON-COMPETING CONTINUATION	$1,101,479
														Subtotal = $1,101,479

Issue Date FY: 2014 ( Subtotal = $1,031,739 )
2014	2014	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	1	7/15/2014	NEW	$1,031,739
														Subtotal = $1,031,739

Grand Total All Awards = $5,203,476

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Monitoring SIV Reservoirs with Whole Body immunoPET

Award Number: R01AI111907

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2014

PERIOD OF PERFORMANCE END DATE: 06/30/2020

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