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Latitudinal Landscape Genomics and Ecology of Anopheles Darlingi

Award Number: R01AI110112
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2014
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Latitudinal Landscape Genomics and Ecology of Anopheles Darlingi - Project Summary Despite major progress in malaria reduction in Latin America from 2005-2015, malaria cases have again increased to nearly one million in the last few years, with 75% of these cases reported in Venezuela and Brazil. We emphasize that ecological variables (such as ecotones and land use classes) that impact the primary neotropical vector Anopheles darlingi (in Brazil and Venezuela) and the regional vector An. albitarsis s.l. (equal in importance to An. darlingi in Venezuela) are largely unquantified or unidentified, constituting a major information gap. The premise of the proposed study is that human-modified landscape types (riverine, mining, agricultural) in persistent malaria hotspots differ significantly in measurable determinants of transmission (ecological, entomological, socioeconomic). Quantification of these determinants in landscape types in Venezuela and Brazil is essential for malaria surveillance to facilitate local targeted interventions to most effectively reduce transmission. Coupling these measures with landscape genomics, we propose to identify and quantify, in a spatially explicit way, landscape features affecting microevolution of malaria vectors. This will provide new insights into local vector adaptation in heterogeneous landscapes, and will help determine why neotropical malaria hotspots persist, at times over multiple years, in certain geographic locations. We hypothesize that the ecological drivers of abundance, proliferation and survival in An. darlingi and An. albitarsis s.l. will differ significantly due to unique ecological signatures (niches) of each species. We anticipate that our findings will provide new information about differential habitat suitability that can be applied throughout the broad and largely overlapping distributions of An. darlingi and An. albitarsis s.l. Polymorphism discovery through whole genome resequencing, integrated with measures of entomological and socioeconomic factors that intensify human-vector contact, will reveal the evolutionary genetic basis of factors promoting vector proliferation and connectivity among vector populations, allowing for more effective vector surveillance. A key remaining issue in our understanding of the role of An. darlingi landscape genomics in malaria transmission is whether gene flow contributes to rapid adaptation and colonization of deforested/degraded habitats throughout the Amazon Basin. We will employ landscape genomics at a regional scale in both Brazil and Venezuela to test whether An. darlingi maintains genetic connectivity or is isolated by resistance across ecotones punctuated by high forest cover. Whereas population genetic surveys based on RADseq or individual genes can detect overall population structure, whole genome sequencing studies have shown that these limited surveys may miss important patterns of ancestry, gene flow and evidence of adaptation (Anopheles gambiae 1000 Genomes Consortium 2017). Herein we present an integrated approach to identify and quantify ecological, entomological and socioeconomic drivers of malaria transmission, based on multi-scale analysis of An. darlingi and An. albitarsis s.l. collected under natural field conditions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $419,524 )
2024	2024	HEALTH RESEARCH, INC.	150 BROADWAY STE 280	MENANDS	NY	12204	ALBANY	USA	Allergy and Infectious Diseases Research	000	10	8/9/2024	NON-COMPETING CONTINUATION	$419,524
														Subtotal = $419,524

Issue Date FY: 2023 ( Subtotal = $401,519 )
2023	2023	HEALTH RESEARCH, INC.	STE 280, RIVERVIEW CENTER	MENANDS	NY	12204	ALBANY	USA	Allergy and Infectious Diseases Research	000	9	8/22/2023	NON-COMPETING CONTINUATION	$401,519
														Subtotal = $401,519

Issue Date FY: 2022 ( Subtotal = $384,644 )
2022	2022	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	000	8	7/28/2022	NON-COMPETING CONTINUATION	$381,230
2022	2018	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	001	5	9/23/2022	NON-COMPETING CONTINUATION	$3,414
														Subtotal = $384,644

Issue Date FY: 2021 ( Subtotal = $378,089 )
2021	2021	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	003	7	8/12/2021	NON-COMPETING CONTINUATION	$378,089
2021	2020	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	000	6	2/3/2021	COMPETING CONTINUATION	$0
2021	2020	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	002	6	7/6/2021	COMPETING CONTINUATION	$13,975
2021	2018	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	001	5	7/6/2021	NON-COMPETING CONTINUATION	-$13,975
														Subtotal = $378,089

Issue Date FY: 2020 ( Subtotal = $376,058 )
2020	2020	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	003	6	9/2/2020	COMPETING CONTINUATION	$20,139
2020	2020	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	002	6	8/28/2020	COMPETING CONTINUATION	$355,919
2020	2018	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	000	5	6/4/2020	NON-COMPETING CONTINUATION	$0
2020	2018	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	001	5	8/20/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $376,058

Issue Date FY: 2018 ( Subtotal = $367,666 )
2018	2018	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	000	5	5/16/2018	NON-COMPETING CONTINUATION	$367,666
														Subtotal = $367,666

Issue Date FY: 2017 ( Subtotal = $338,377 )
2017	2017	HEALTH RESEARCH, INC.	EMPIRE STATE PLAZA	ALBANY	NY	12237	ALBANY	USA	Allergy and Infectious Diseases Research	000	4	5/17/2017	NON-COMPETING CONTINUATION	$338,377
														Subtotal = $338,377

Issue Date FY: 2016 ( Subtotal = $354,517 )
2016	2016	HEALTH RESEARCH, INC - ALBANY DIVISION	1 UNIVERSITY PLACE	RENSSELAER	NY	12144	RENSSELAER	USA	Allergy and Infectious Diseases Research	000	3	5/13/2016	NON-COMPETING CONTINUATION	$354,517
														Subtotal = $354,517

Issue Date FY: 2015 ( Subtotal = $332,609 )
2015	2015	HEALTH RESEARCH, INC - ALBANY DIVISION	1 UNIVERSITY PLACE	RENSSELAER	NY	12144	RENSSELAER	USA	Allergy and Infectious Diseases Research	000	2	5/4/2015	NON-COMPETING CONTINUATION	$332,609
														Subtotal = $332,609

Issue Date FY: 2014 ( Subtotal = $328,319 )
2014	2014	HEALTH RESEARCH, INC - ALBANY DIVISION	1 UNIVERSITY PLACE	RENSSELAER	NY	12144	RENSSELAER	USA	Allergy and Infectious Diseases Research	000	1	6/6/2014	NEW	$328,319
														Subtotal = $328,319

Grand Total All Awards = $3,681,322

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Latitudinal Landscape Genomics and Ecology of Anopheles Darlingi

Award Number: R01AI110112

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2014

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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