Saturday, February 14, 2026 2/14/2026

Novel Influenza nano vaccines for broad cross protection

Award Number: R01AI101047
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2012
PERIOD OF PERFORMANCE END DATE: 06/30/2026

Group Awards By:

View Award Description

Novel Influenza nano vaccines for broad cross protection - SUMMARY Influenza is a major public health risk. The current seasonal influenza vaccine is effective against closely matched viruses in healthy adults, but it cannot prevent the outbreaks of epidemics or pandemics because influenza viruses mutate frequently and zoonotic strains can jump the species barrier into humans. Other disadvantages of the seasonal influenza vaccine include the need to produce new vaccines every season, the uncertainty in selecting vaccine strains, and the compromised efficacy for mismatched viruses. A novel generation of influenza vaccines, termed universal influenza vaccines, will overcome these challenges. In the previous grant period, we have produced layered protein nanoparticles (nanoclusters) from conserved HA stalk antigens and the M2 protein ectodomain of influenza A. Nanocluster immunizations induced cross protection against viruses from both phylogenic groups of influenza A, including pandemic-potential avian strains. Both influenza A and influenza B cause influenza epidemics in humans. In this proposal, we propose to construct a multivalent layered nanocluster formulation composed of newly designed antigenic proteins from both influenza A and influenza B as a universal influenza vaccine. The new vaccine will induce broad cross- protection against both influenza types. We have three specific aims: Aim 1. To design and construct conserved antigens from influenza A and B, fabricate nanoclusters from these and previously designed antigenic proteins, and characterize these new nanoclusters. We will optimize the orchestration, composition, and stability of these nanoclusters for the physiologically-activated release of free antigenic proteins, antigen-processing and presentation after the uptake by dendritic cells, distribution of these nanoclusters to draining lymph nodes, and induction of strong antigen-specific immune responses in mice. Aim 2. To test whether these layered nanoclusters or an optimal combination will induce broadly reactive immune responses and whether the immunity will grant cross-protection against viruses spanning both influenza A and influenza B in mice. Aim 3. To test whether the leading multivalent nanocluster combinations will induce robust immune responses which confer broad cross-protection in ferrets. Overall, our research will develop a broadly cross-protective universal influenza vaccine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	000	10	8/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $646,873 )
2023	2023	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC	58 EDGEWOOD AVE NE	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	000	10	6/28/2023	NON-COMPETING CONTINUATION	$646,873
														Subtotal = $646,873

Issue Date FY: 2022 ( Subtotal = $663,476 )
2022	2022	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	000	9	6/24/2022	NON-COMPETING CONTINUATION	$663,476
														Subtotal = $663,476

Issue Date FY: 2021 ( Subtotal = $630,929 )
2021	2021	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	000	8	6/21/2021	NON-COMPETING CONTINUATION	$630,929
														Subtotal = $630,929

Issue Date FY: 2020 ( Subtotal = $652,846 )
2020	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	002	7	7/7/2020	NON-COMPETING CONTINUATION	$652,846
2020	2020	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	003	7	8/20/2020	NON-COMPETING CONTINUATION	$0
2020	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	001	6	12/20/2019	COMPETING CONTINUATION	$3
2020	2016	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	000	5	12/20/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$3
														Subtotal = $652,846

Issue Date FY: 2019 ( Subtotal = $664,253 )
2019	2019	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	000	6	6/27/2019	COMPETING CONTINUATION	$664,253
														Subtotal = $664,253

Issue Date FY: 2018 ( Subtotal = -$3 )
2018	2016	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	000	5	3/23/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2018	2016	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.	58 EDGEWOOD AVE NE 3RD FL	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	002	5	5/9/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,804
2018	2015	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	4	5/9/2018	NON-COMPETING CONTINUATION	-$2,807
														Subtotal = -$3

Issue Date FY: 2016 ( Subtotal = $597,227 )
2016	2016	GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION	33 GILMER STREET SOUTHEAST	ATLANTA	GA	30303	FULTON	USA	Allergy and Infectious Diseases Research	000	5	5/6/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$597,227
														Subtotal = $597,227

Issue Date FY: 2015 ( Subtotal = $588,555 )
2015	2015	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	4	4/7/2015	NON-COMPETING CONTINUATION	$588,555
														Subtotal = $588,555

Issue Date FY: 2014 ( Subtotal = $579,189 )
2014	2014	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	3	4/11/2014	NON-COMPETING CONTINUATION	$579,189
														Subtotal = $579,189

Issue Date FY: 2013 ( Subtotal = $521,571 )
2013	2013	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	2	4/5/2013	NON-COMPETING CONTINUATION	$499,377
2013	2013	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	2	4/17/2013	NON-COMPETING CONTINUATION	$0
2013	2013	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	2	5/31/2013	NON-COMPETING CONTINUATION	$22,194
														Subtotal = $521,571

Issue Date FY: 2012 ( Subtotal = $553,128 )
2012	2012	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	002	1	8/14/2012	NEW	$157,218
2012	2012	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	001	1	5/11/2012	NEW	$0
2012	2012	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	1	5/10/2012	NEW	$395,910
2012	2012	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	003	1	8/24/2012	NEW	$0
														Subtotal = $553,128

Grand Total All Awards = $6,098,044

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Novel Influenza nano vaccines for broad cross protection

Award Number: R01AI101047

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2012

PERIOD OF PERFORMANCE END DATE: 06/30/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer