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Host vulnerability and parasite genetics in the development of cerebral malaria

Award Number: R01AI099628
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2014
PERIOD OF PERFORMANCE END DATE: 03/31/2020

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Host vulnerability and parasite genetics in the development of cerebral malaria - DESCRIPTION (provided by applicant): Malaria kills approximately one million children each year. However, immunity to malaria severe enough to require hospital admission appears to develop quickly - after only one or two infections, such that the risk of severe disease drops significantly following infancy. The development of this protective natural immunity to malaria correlates with the production of antibodies to malaria parasite antigens that are expressed on the surface of infected erythrocytes. Each malaria parasite possesses a large number of distinct genes encoding these potential parasite surface antigens. Work at our field site in Mali suggests that parasites express a "stealth" subgroup of these antigens more commonly in cerebral malaria - the deadliest form of severe malaria - than in milder forms of malaria. How important is an individual's development of antibodies to parasite surface antigens, particularly this "stealth" subgroup, in the acquisition of immunity to cerebral malaria? This project will measure the association between the risk of cerebral malaria and the presence of antibodies to these parasite surface antigens, with a particular focus on the "stealth" subgroup. We have completed several studies that compare children with cerebral malaria to children who have milder forms of malaria or who are healthy. We will take archived sera from these studies to see how well antibodies bind peptide sequences of surface antigens expressed by malaria parasites. These peptide sequences will come from both surface antigens previously isolated in these studies and, in the second part of our project, a new study of children with cerebral malaria. Multiple peptide sequences will be encoded onto microarray chips, which will then be washed with sera to allow us to study antibody interactions with all of these parasite peptide sequences at once. We predict that sera from young children will not recognize many parasite surface antigen peptide sequences. We also expect that infected children with mild or no malaria symptoms harbor malaria parasites that are recognized by their antibodies, limiting the extent of disease. In contrast, sera from children with cerebral malaria will not recognize peptide sequences of parasite surface antigens as well, particularly not the "stealth" surface antigens associated with cerebral malaria. If this is indeed the case, such "stealth" surface antigens may comprise a potential target for a malaria vaccine to protect against cerebral malaria.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = -$6 )
2020	2018	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	5	9/2/2020	NON-COMPETING CONTINUATION	-$6
														Subtotal = -$6

Issue Date FY: 2018 ( Subtotal = $119,068 )
2018	2018	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	5	3/28/2018	NON-COMPETING CONTINUATION	$119,068
														Subtotal = $119,068

Issue Date FY: 2017 ( Subtotal = $119,068 )
2017	2017	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	4	3/27/2017	NON-COMPETING CONTINUATION	$119,068
														Subtotal = $119,068

Issue Date FY: 2016 ( Subtotal = $126,844 )
2016	2016	UNIVERSITY OF MALI	Campus de Badalabougou	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	3	3/28/2016	NON-COMPETING CONTINUATION	$126,844
														Subtotal = $126,844

Issue Date FY: 2015 ( Subtotal = $125,845 )
2015	2015	UNIVERSITY OF MALI	Campus de Badalabougou	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	2	3/12/2015	NON-COMPETING CONTINUATION	$125,845
														Subtotal = $125,845

Issue Date FY: 2014 ( Subtotal = $134,371 )
2014	2014	UNIVERSITY OF MALI	Campus de Badalabougou	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	1	4/15/2014	NEW	$134,371
														Subtotal = $134,371

Grand Total All Awards = $625,190

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Host vulnerability and parasite genetics in the development of cerebral malaria

Award Number: R01AI099628

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2014

PERIOD OF PERFORMANCE END DATE: 03/31/2020

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