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Mechanisms mediating HCMV genome maintenance during latency

Award Number: R01AI099372
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2013
PERIOD OF PERFORMANCE END DATE: 11/30/2019

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Mechanisms mediating HCMV genome maintenance during latency - DESCRIPTION (provided by applicant): Human cytomegalovirus (CMV) infections are a substantial source of morbidity and mortality in transplant recipients, and a major cause of long-term disabilities in congenitally infected children. Because of this, the development of new antiviral therapies is urgently needed. The ability of this virus to undergo lifelong latency and reactivation cycles, however, represents a formidable obstacle in our progress towards this goal. Here, we propose to use two in vitro models of CMV latency in hematopoietic cells to conclusively establish if and how maintenance of latent viral genomes is achieved in dividing myeloid progenitor cells. This work will provide significant insights into a crucial aspect of CMV latency, and will constitute the foundation for the development of innovative therapies with the potential to eradicate this virus from the human population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$366,912 )
2023	2017	CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND	747 52ND ST	OAKLAND	CA	94609	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	5	10/1/2022	NON-COMPETING CONTINUATION	-$366,912
														Subtotal = -$366,912

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND	747 52ND ST	OAKLAND	CA	94609	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	5	4/15/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND	747 52ND ST	OAKLAND	CA	94609	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	5	6/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $408,750 )
2017	2017	CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND	747 52ND ST	OAKLAND	CA	94609	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	5	3/17/2017	NON-COMPETING CONTINUATION	$408,750
														Subtotal = $408,750

Issue Date FY: 2016 ( Subtotal = $408,750 )
2016	2016	CHILDRENS HOSP. & RESEARCH CTR OF OAKLAND	747 52ND STREET	OAKLAND	CA	94609	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	4	3/14/2016	EXTENSION WITH OR WITHOUT FUNDS	$408,750
														Subtotal = $408,750

Issue Date FY: 2015 ( Subtotal = $408,750 )
2015	2015	CHILDRENS HOSP. & RESEARCH CTR OF OAKLAND	747 52ND STREET	OAKLAND	CA	94609	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	3	3/17/2015	NON-COMPETING CONTINUATION	$408,750
														Subtotal = $408,750

Issue Date FY: 2014 ( Subtotal = $408,750 )
2014	2014	CHILDRENS HOSP. & RESEARCH CTR OF OAKLAND	747 52ND STREET	OAKLAND	CA	94609	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	2	3/18/2014	NON-COMPETING CONTINUATION	$408,750
														Subtotal = $408,750

Issue Date FY: 2013 ( Subtotal = $160,094 )
2013	2013	CHILDRENS HOSP. & RESEARCH CTR OF OAKLAND	747 52ND STREET	OAKLAND	CA	94609	ALAMEDA	USA	Allergy and Infectious Diseases Research	001	1	9/23/2013	NEW	$6,813
2013	2013	CHILDRENS HOSP. & RESEARCH CTR OF OAKLAND	747 52ND STREET	OAKLAND	CA	94609	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	1	4/10/2013	NEW	$153,281
														Subtotal = $160,094

Grand Total All Awards = $1,428,182

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Mechanisms mediating HCMV genome maintenance during latency

Award Number: R01AI099372

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2013

PERIOD OF PERFORMANCE END DATE: 11/30/2019

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