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Monkeypox virus, Interferon, and Necroptosis

Award Number: R01AI095394
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/24/2012
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Monkeypox virus, Interferon, and Necroptosis - Much of what we know about poxvirus innate immune evasion comes from work with the prototype orthopoxvirus, vaccinia virus (VACV). However, it is becoming clear that what we know for VACV is not always true for other poxviruses. The example we have been working on is monkeypox virus (MPXV). VACV has an E3L gene, which is essential for interferon-resistance, both in cells in culture and in the animal model. Despite being highly pathogenic, MPXV is missing 37 residues from the N-terminus of its E3 homologue. Thus, it is surprising that MPXV is as pathogenic as it is, despite missing this essential region of the E3 innate immune evasion protein. We have shown that while the lack of an N-terminal innate immune evasion domain in MPXV allows the virus to be sensed by the host, MPXV has evolved at least two apparently independent mechanisms to overcome the effects of being sensed in cells. The goals of this research are to understand how this unique human pathogen is sensed in infected cells and how it has evolved to counter the effects of sensing. Loss of this innate immune evasion domain makes vaccination against MPXV problematic. The final goal of this project is to develop a vaccine that can safely protect against MPXV infection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $420,608 )
2024	2024	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Allergy and Infectious Diseases Research	000	10	8/1/2024	NON-COMPETING CONTINUATION	$420,608
														Subtotal = $420,608

Issue Date FY: 2023 ( Subtotal = $418,253 )
2023	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Allergy and Infectious Diseases Research	000	9	9/6/2023	NON-COMPETING CONTINUATION	$418,253
														Subtotal = $418,253

Issue Date FY: 2022 ( Subtotal = $541,174 )
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Allergy and Infectious Diseases Research	000	8	8/8/2022	NON-COMPETING CONTINUATION	$541,174
														Subtotal = $541,174

Issue Date FY: 2021 ( Subtotal = $476,833 )
2021	2021	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Allergy and Infectious Diseases Research	000	7	7/22/2021	NON-COMPETING CONTINUATION	$476,833
														Subtotal = $476,833

Issue Date FY: 2020 ( Subtotal = $538,257 )
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Allergy and Infectious Diseases Research	000	6	8/18/2020	COMPETING CONTINUATION	$538,257
														Subtotal = $538,257

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Allergy and Infectious Diseases Research	000	5	8/13/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $671,400 )
2016	2016	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Allergy and Infectious Diseases Research	000	5	4/6/2016	EXTENSION WITH OR WITHOUT FUNDS	$671,400
														Subtotal = $671,400

Issue Date FY: 2015 ( Subtotal = $692,150 )
2015	2015	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Allergy and Infectious Diseases Research	000	4	4/22/2015	NON-COMPETING CONTINUATION	$692,150
														Subtotal = $692,150

Issue Date FY: 2014 ( Subtotal = $382,999 )
2014	2014	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Allergy and Infectious Diseases Research	000	3	4/16/2014	NON-COMPETING CONTINUATION	$382,999
														Subtotal = $382,999

Issue Date FY: 2013 ( Subtotal = $360,019 )
2013	2013	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Allergy and Infectious Diseases Research	000	2	4/18/2013	NON-COMPETING CONTINUATION	$344,698
2013	2013	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Allergy and Infectious Diseases Research	001	2	6/5/2013	NON-COMPETING CONTINUATION	$15,321
														Subtotal = $360,019

Issue Date FY: 2012 ( Subtotal = $382,999 )
2012	2012	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Allergy and Infectious Diseases Research	000	1	5/23/2012	NEW	$382,999
														Subtotal = $382,999

Grand Total All Awards = $4,884,692

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Monkeypox virus, Interferon, and Necroptosis

Award Number: R01AI095394

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/24/2012

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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