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Respiratory Syncytial Virus Targeting of the Human Airway Epithelium

Award Number: R01AI093848
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2011
PERIOD OF PERFORMANCE END DATE: 12/31/2024

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Respiratory Syncytial Virus Targeting of the Human Airway Epithelium - Abstract: Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization for infants and young children, but no vaccines or antiviral drugs are yet available. RSV infects the cells that line the nose, trachea and smaller airways. The overall goal of the laboratory is to understand how RSV infects its target cell, the ciliated airway cell, and to use that information to develop better vaccine and antiviral drug candidates. This laboratory uses primary well differentiated human airway epithelial cultures (HAECs) to study RSV infection. These HAECs have recently been used to identify an important RSV receptor on the ciliated airway cells. Preliminary data presented here demonstrate that the RSV produced by these HAECs is much more infectious for HAECs than for immortalized cells and its attachment, G, glycoprotein is responsible for this difference. The G protein is modified differently in HAECs as it passes through the cell, on its way to being incorporated into the RSV virion at the plasma membrane and this modification may be responsible for its enhanced activity. This project will identify the modification and the mechanism by which it is made. RSV also produces a secreted form of the G protein that triggers immune cells to migrate toward RSV-infected cells. This project will also determine if this secreted G protein is modified like the full-length version, and if its signaling activity is changed or enhanced by its modification, similar to the full-length G protein. Once the modification of the G protein and the secreted G protein are identified, and the mechanism by which they are modified are identified, this information could enable the production of more effective and economical live attenuated vaccines for RSV and provide targets for novel antiviral agents. This project will advance the NIH Mission of developing “fundamental knowledge to extend healthy life and reduce the burdens of illness.”


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$320 )
2025	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	10	5/7/2025	NON-COMPETING CONTINUATION	-$320
														Subtotal = -$320

Issue Date FY: 2023 ( Subtotal = $369,528 )
2023	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	10	12/15/2022	NON-COMPETING CONTINUATION	$369,528
														Subtotal = $369,528

Issue Date FY: 2022 ( Subtotal = $368,900 )
2022	2022	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	001	9	12/17/2021	NON-COMPETING CONTINUATION	$369,833
2022	2016	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	5	10/1/2021	EXTENSION WITH OR WITHOUT FUNDS	-$933
														Subtotal = $368,900

Issue Date FY: 2021 ( Subtotal = $370,129 )
2021	2021	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	8	12/21/2020	NON-COMPETING CONTINUATION	$370,129
														Subtotal = $370,129

Issue Date FY: 2020 ( Subtotal = $399,391 )
2020	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	001	7	2/11/2020	SUPPLEMENT FOR EXPANSION	$28,974
2020	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	7	12/27/2019	NON-COMPETING CONTINUATION	$370,417
														Subtotal = $399,391

Issue Date FY: 2019 ( Subtotal = $370,696 )
2019	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	6	1/17/2019	COMPETING CONTINUATION	$370,696
														Subtotal = $370,696

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	5	4/4/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $362,000 )
2016	2016	Research Institute at Nationwide`s Children`s Hospital	700 CHILDREN`S DRIVE	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	5	11/25/2015	EXTENSION WITH OR WITHOUT FUNDS	$362,000
														Subtotal = $362,000

Issue Date FY: 2015 ( Subtotal = $409,000 )
2015	2015	Research Institute at Nationwide`s Children`s Hospital	700 CHILDREN`S DRIVE	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	4	11/11/2014	NON-COMPETING CONTINUATION	$409,000
														Subtotal = $409,000

Issue Date FY: 2014 ( Subtotal = $444,040 )
2014	2014	Research Institute at Nationwide`s Children`s Hospital	700 CHILDREN`S DRIVE	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	001	3	6/27/2014	NON-COMPETING CONTINUATION	$44,404
2014	2014	Research Institute at Nationwide`s Children`s Hospital	700 CHILDREN`S DRIVE	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	3	11/25/2013	NON-COMPETING CONTINUATION	$399,636
														Subtotal = $444,040

Issue Date FY: 2013 ( Subtotal = $377,516 )
2013	2013	Research Institute at Nationwide`s Children`s Hospital	700 CHILDREN`S DRIVE	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	001	2	5/30/2013	NON-COMPETING CONTINUATION	$14,480
2013	2013	Research Institute at Nationwide`s Children`s Hospital	700 CHILDREN`S DRIVE	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	002	2	7/10/2013	SUPPLEMENT FOR EXPANSION	$37,236
2013	2013	Research Institute at Nationwide`s Children`s Hospital	700 CHILDREN`S DRIVE	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	2	12/5/2012	NON-COMPETING CONTINUATION	$325,800
														Subtotal = $377,516

Issue Date FY: 2012 ( Subtotal = $362,000 )
2012	2012	Research Institute at Nationwide`s Children`s Hospital	700 CHILDREN`S DRIVE	COLUMBUS	OH	43205	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	1	11/17/2011	NEW	$362,000
														Subtotal = $362,000

Grand Total All Awards = $3,832,880

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Respiratory Syncytial Virus Targeting of the Human Airway Epithelium

Award Number: R01AI093848

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2011

PERIOD OF PERFORMANCE END DATE: 12/31/2024

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