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Genome-wide association study of febrile seizures following measles, mumps, rubel

Award Number: R01AI093697
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/08/2012
PERIOD OF PERFORMANCE END DATE: 05/31/2016

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Genome-wide association study of febrile seizures following measles, mumps, rubel - DESCRIPTION (provided by applicant): While vaccination is one of the most effective public health interventions, stringent attention must be paid to its safety. Vaccines in national vaccination programs are generally safe, but on rare occasions some individuals experience serious adverse events. In addition to the suffering of the individual, the occurrence of adverse events may also compromise public confidence in vaccination. If researchers and clinicians can learn through which mechanisms adverse events occur, they will be able to improve the design of vaccines to make them safer, develop tests to predict risk of adverse events and, subsequently, take appropriate preventive measures in certain high risk individuals. An increased risk of febrile seizures has been observed in children in the immediate period following administration of the measles, mumps and rubella (MMR) vaccine. It has been estimated that 3 to 16 additional cases of febrile seizures per 10,000 children can be attributed to MMR vaccination. Preliminary studies have suggested that adverse events of vaccination may have genetic determinants. The aim of this project is to investigate whether any genetic variants (polymorphisms) are associated with increased risk of febrile seizures following MMR vaccination. This project, the first of its kind, will apply modern genetics technology and analyze more than 1,000,000 genetic variants in 1000 children who have suffered febrile seizures following MMR vaccination, 1000 children who have suffered febrile seizures unrelated to MMR vaccination and 1000 healthy controls. A replication study, always necessary to verify results in large genetics studies, will involve an additional 2000 children. The project will take advantage of the exceptional research resources available in Denmark and will combine health information from nationwide registers with genetic information based on samples obtained from a national biobank. This study will not only provide new insights into the safety of the MMR vaccine, but will demonstrate the feasibility and value of studying the genetics of vaccine safety in general.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$1 )
2017	2015	STATENS SERUM INSTITUT	ARTILLERIVEJ 5	KOBENHAVN S		2300		DNK	Allergy and Infectious Diseases Research	000	4	11/2/2016	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2015 ( Subtotal = $92,703 )
2015	2015	STATENS SERUM INSTITUTE	ORESTADS BOULEVARD 5	COPENHAGEN				DNK	Allergy and Infectious Diseases Research	000	4	6/15/2015	NON-COMPETING CONTINUATION	$92,703
														Subtotal = $92,703

Issue Date FY: 2014 ( Subtotal = $193,478 )
2014	2014	STATENS SERUM INSTITUTE	ORESTADS BOULEVARD 5	COPENHAGEN				DNK	Allergy and Infectious Diseases Research	000	3	6/24/2014	NON-COMPETING CONTINUATION	$193,478
														Subtotal = $193,478

Issue Date FY: 2013 ( Subtotal = $188,951 )
2013	2013	STATENS SERUM INSTITUTE	5 ARTILLERIVEJ	COPENHAGEN				DNK	Allergy and Infectious Diseases Research	000	2	6/7/2013	EXTENSION WITH OR WITHOUT FUNDS	$188,951
														Subtotal = $188,951

Issue Date FY: 2012 ( Subtotal = $113,400 )
2012	2012	STATENS SERUM INSTITUTE	5 ARTILLERIVEJ	COPENHAGEN				DNK	Allergy and Infectious Diseases Research	000	1	5/31/2012	NEW	$113,400
														Subtotal = $113,400

Grand Total All Awards = $588,531

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Genome-wide association study of febrile seizures following measles, mumps, rubel

Award Number: R01AI093697

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/08/2012

PERIOD OF PERFORMANCE END DATE: 05/31/2016

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