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Antiviral Drugs for Arenaviruses

Award Number: R01AI093387
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/17/2011
PERIOD OF PERFORMANCE END DATE: 07/31/2016

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Antiviral Drugs for Arenaviruses - DESCRIPTION (provided by applicant): The goal of the program described here is to develop an antiviral drug for treating and preventing Lassa fever and other hemorrhagic fevers of arenavirus origin. Previous library screening identified several good candidate small molecule inhibitors of Lassa virus entry. Subsequent in vitro and in vivo characterization identified a potent series, ST-193, with broad- spectrum activity against 5 distinct Category A hemorrhagic fever Arenaviruses. This series has shown protective efficacy in two animal models of Lassa fever, guinea pigs and cynomolgus monkeys. The specific objective of this application is to optimize this chemical series to identify an appropriate candidate for preclinical development and to collect the necessary data to support the submission of an application for an Investigational New Drug (IND).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	KINETA, INC.	219 TERRY AVE N STE 300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	5	12/7/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2014	KINETA, INC.	219 TERRY AVE N STE 300	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	001	4	3/20/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$28,275
2017	2013	SIGA TECHNOLOGIES, INC.	27 E 62ND ST	NEW YORK	NY	10065	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	3/20/2017	NON-COMPETING CONTINUATION	-$28,275
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $1,296,933 )
2015	2015	KINETA INC	307 WESTLAKE AVENUE NORTH	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	5	7/30/2015	NON-COMPETING CONTINUATION	$1,296,933
														Subtotal = $1,296,933

Issue Date FY: 2014 ( Subtotal = $1,228,837 )
2014	2014	KINETA INC	307 WESTLAKE AVENUE NORTH	SEATTLE	WA	98109	KING	USA	Allergy and Infectious Diseases Research	000	4	7/24/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,228,837
														Subtotal = $1,228,837

Issue Date FY: 2013 ( Subtotal = $1,364,947 )
2013	2013	SIGA TECHNOLOGIES, INC	420 LEXINGTON AVENUE	NEW YORK	NY	10170	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	7/1/2013	NON-COMPETING CONTINUATION	$1,364,947
														Subtotal = $1,364,947

Issue Date FY: 2012 ( Subtotal = $1,435,943 )
2012	2012	SIGA TECHNOLOGIES, INC	420 LEXINGTON AVENUE	NEW YORK	NY	10170	NEW YORK	USA	Allergy and Infectious Diseases Research	000	2	7/18/2012	NON-COMPETING CONTINUATION	$1,435,943
														Subtotal = $1,435,943

Issue Date FY: 2011 ( Subtotal = $1,779,213 )
2011	2011	SIGA TECHNOLOGIES, INC	420 LEXINGTON AVENUE	NEW YORK	NY	10170	NEW YORK	USA	Allergy and Infectious Diseases Research	000	1	8/17/2011	NEW	$1,779,213
														Subtotal = $1,779,213

Grand Total All Awards = $7,105,873

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Antiviral Drugs for Arenaviruses

Award Number: R01AI093387

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/17/2011

PERIOD OF PERFORMANCE END DATE: 07/31/2016

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