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HIV associated Lipodystrophy Syndrome in Children: Role of nutrition, ART & Genes

Award Number: R01AI084390
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2011
PERIOD OF PERFORMANCE END DATE: 03/31/2016

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HIV associated Lipodystrophy Syndrome in Children: Role of nutrition, ART & Genes - DESCRIPTION (provided by applicant): An increasing number of HIV infected children are being started on stavudine containing antiretroviral treatment regimens in India. The incidence and pattern of metabolic complications among these children are not known. We propose to conduct a prospective study at two sites in South India to study the incidence and risk factors for the development of metabolic complications and body shape abnormalities among HIV infected children between the ages of 2 and 10 years, after 12 months of ART. Specifically, we will study the role of genetic factors (single nucleotide polymorphisms in APOA5, APOC3, APOE, CETP and PLIN genes) in the development of metabolic complications, namely fat redistribution, insulin resistance and dyslipidemia. 400 HIV infected children will be studied prospectively, at 2 sites in South India. Various risk factors and lipid gene polymorphism will be correlated with lipodystrophy, lipoatrophy, dyslipidemia and insulin resistance. The study will provide information, not currently available, on the metabolic complication of HIV and ART, in children between the ages of 2 and 10 years of age after 12 months of Stavudine containing antiretroviral treatment regimen. This knowledge of risk factors will be crucial to inform physicians and policy makers in order to design better treatment strategies for children.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2014	NATIONAL INSTITUTE FOR RESEARCH IN TUBERCULOSIS	SPUR TANK ROAD	CHENNAI					Allergy and Infectious Diseases Research	000	4	6/12/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $122,593 )
2014	2014	TUBERCULOSIS RESEARCH CENTRE	AMARGADH AMARGADH AMARGADH, TB HOSP	AMRELI				IND	Allergy and Infectious Diseases Research	000	4	5/9/2014	NON-COMPETING CONTINUATION	$122,593
														Subtotal = $122,593

Issue Date FY: 2013 ( Subtotal = $115,238 )
2013	2013	TUBERCULOSIS RESEARCH CENTRE	AMARGADH AMARGADH AMARGADH, TB HOSP	AMRELI				IND	Allergy and Infectious Diseases Research	000	3	4/9/2013	EXTENSION WITH OR WITHOUT FUNDS	$110,333
2013	2013	TUBERCULOSIS RESEARCH CENTRE	AMARGADH AMARGADH AMARGADH, TB HOSP	AMRELI				IND	Allergy and Infectious Diseases Research	001	3	6/28/2013	EXTENSION WITH OR WITHOUT FUNDS	$4,905
														Subtotal = $115,238

Issue Date FY: 2012 ( Subtotal = $122,593 )
2012	2012	TUBERCULOSIS RESEARCH CENTRE	AMARGADH AMARGADH AMARGADH, TB HOSP	AMRELI				IND	Allergy and Infectious Diseases Research	000	2	4/26/2012	NON-COMPETING CONTINUATION	$122,593
														Subtotal = $122,593

Issue Date FY: 2011 ( Subtotal = $122,593 )
2011	2011	TUBERCULOSIS RESEARCH CENTRE	AMARGADH AMARGADH AMARGADH, TB HOSP	AMRELI				IND	Allergy and Infectious Diseases Research	000	1	3/31/2011	NEW	$122,593
														Subtotal = $122,593

Grand Total All Awards = $483,017

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HIV associated Lipodystrophy Syndrome in Children: Role of nutrition, ART & Genes

Award Number: R01AI084390

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2011

PERIOD OF PERFORMANCE END DATE: 03/31/2016

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