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A Model System for Host Pathogen Interaction: Drosophila and Its Parasitic Wasps

Award Number: R01AI081879
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/01/2016
PERIOD OF PERFORMANCE END DATE: 07/31/2020

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A Model System for Host Pathogen Interaction: Drosophila and Its Parasitic Wasps - DESCRIPTION (provided by applicant): Although Drosophila melanogaster is a model system for the molecular genetics of innate immunity, virtually nothing is known about the life history and virulence strategies of its natural parasites. Parasitic wasps can infect Drosophila larvae at frequencies greater than 50% in natural populations, and are highly amenable to laboratory and field study. The Schlenke lab has developed a collection of 17 live wasp parasite strains of Drosophila, and robust protocols for extracting and manipulating the venom cocktails they use to thwart the host cellular encapsulation response mounted against their eggs. In this application, Schlenke proposes to use a joint transcriptomic and proteomic approach to identify the venom gland contents of 10 related wasp species that are highly successful infectors of D. melanogaster. He will then assay the effects of whole venom from each wasp species using two types of assays: First, he will assay the effects of venom on the structure and function of D. melanogaster hemocytes ex vivo. Second, he will assay encapsulation defects in vivo by injecting oil droplets into flies, which are readily melanotically encapsulated, mixed with venom fractions. For any immune suppressive effects that whole venom has, Schlenke will then identify venom fractions and individual venom proteins responsible for these characterized venom effects. Finally, Schlenke will use population genetic and molecular evolution approaches to uncover how venoms maintain virulence function in their co-evolutionary arms race with host immune systems. In sum, Schlenke hopes to develop the Drosophila-wasp system as a model for the study of eukaryotic host-pathogen interactions and for the evolution of parasite life histories.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2017	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	000	9	2/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	000	9	12/4/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $317,512 )
2017	2017	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	004	9	7/28/2017	NON-COMPETING CONTINUATION	$363,996
2017	2017	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	002	9	7/11/2017	NON-COMPETING CONTINUATION	$345,375
2017	2016	REED INSTITUTE, THE	3203 S E WOODSTOCK BLVD	PORTLAND	OR	97202	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	7	3/8/2017	NON-COMPETING CONTINUATION	-$373,238
2017	2016	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Allergy and Infectious Diseases Research	001	8	3/8/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$345,375
2017	2015	REED INSTITUTE, THE	3203 S E WOODSTOCK BLVD	PORTLAND	OR	97202	MULTNOMAH	USA	Allergy and Infectious Diseases Research	003	6	7/28/2017	NON-COMPETING CONTINUATION	-$363,996
														Subtotal = $317,512

Issue Date FY: 2016 ( Subtotal = $373,238 )
2016	2016	REED COLLEGE	3203 E. WOODSTOCK BLVD.	PORTLAND	OR	97202	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	7	6/28/2016	NON-COMPETING CONTINUATION	$373,238
														Subtotal = $373,238

Issue Date FY: 2015 ( Subtotal = $373,238 )
2015	2015	REED COLLEGE	3203 E. WOODSTOCK BLVD.	PORTLAND	OR	97202	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	6	7/14/2015	NON-COMPETING CONTINUATION	$373,238
														Subtotal = $373,238

Issue Date FY: 2014 ( Subtotal = $373,238 )
2014	2014	REED COLLEGE	3203 E. WOODSTOCK BLVD.	PORTLAND	OR	97202	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	5	8/1/2014	COMPETING CONTINUATION	$373,238
														Subtotal = $373,238

Issue Date FY: 2012 ( Subtotal = $341,811 )
2012	2012	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	4	6/15/2012	NON-COMPETING CONTINUATION	$341,811
														Subtotal = $341,811

Issue Date FY: 2011 ( Subtotal = $341,811 )
2011	2011	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	3	7/19/2011	NON-COMPETING CONTINUATION	$341,811
														Subtotal = $341,811

Issue Date FY: 2010 ( Subtotal = $345,263 )
2010	2010	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	2	6/8/2010	NON-COMPETING CONTINUATION	$345,263
														Subtotal = $345,263

Issue Date FY: 2009 ( Subtotal = $373,750 )
2009	2009	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Allergy and Infectious Diseases Research	000	1	7/22/2009	NEW	$373,750
														Subtotal = $373,750

Grand Total All Awards = $2,839,861

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A Model System for Host Pathogen Interaction: Drosophila and Its Parasitic Wasps

Award Number: R01AI081879

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/01/2016

PERIOD OF PERFORMANCE END DATE: 07/31/2020

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