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TRANSMISSION DYNAMICS OF CRYPTOSPORIDIAL INFECTIONS IN INDIA

Award Number: R01AI075452
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2008
PERIOD OF PERFORMANCE END DATE: 02/29/2012

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TRANSMISSION DYNAMICS OF CRYPTOSPORIDIAL INFECTIONS IN INDIA - DESCRIPTION (provided by applicant): The overall goal of this collaborative study is to investigate the transmission dynamics of cryptosporidial infections in children in southern India. In developing countries, cryptosporidiosis is a cause, not only of outbreaks, but also of significant endemic disease and morbidity, resulting in diarrheal disease and long-term consequences such as impaired growth and cognitive function. Although cryptosporidiosis is a cause of immediate and prolonged morbidity, the risk factors that affect acquisition of infection in developing countries are not completely understood. In collaborative studies between the Christian Medical College, Vellore, India and the Tufts-New England Medical Center, we propose to use state-of-the-art epidemiological and molecular methodology to investigate the source and spread of infection to children in this area by assessing risks from the external and domestic environment. In this application, our multidisciplinary team will intensively follow two cohorts of children with protected and unprotected drinking water sources in order to quantify the risk of infection from familial, domestic and environmental sources for a period from weaning and for up to two years in a semi-urban slum area of Vellore, South India, where Cryptosporidium is the most common cause of parasitic diarrhea. This study will determine the time to first cryptosporidial infection in children drinking protected and unprotected water, in the context of maternal antibodies, hygiene, water safety and sanitation practices, as well as potentially transmissible infections in family members, household animals, drinking water and sewage. Molecular information on genotyping will be integrated with clinical and epidemiologic information in a spatial database to build integrated models to assess indicators for infection. The underlying hypothesis is that the time to infection with Cryptosporidium spp. in southern India is dependent on environmental risk factors that can be quantified and modeled. This will be the first prospective study of transmission dynamics of cryptosporidiosis using molecular fingerprinting and geospatial technology. This study has important implications for public health because there are no data from longitudinal studies from developing countries using molecular and geospatial methods to asses the role of familial and environmental risk factors in transmission of cryptosporidiosis in children. These data will provide the basis for the logical development of interventions that are appropriate to the developing country communities in which cryptosporidiosis is common.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2011	CHRISTIAN MEDICAL COLLEGE	POST OFFICE BOX 3	VELLORE		00000			Allergy and Infectious Diseases Research	000	4	12/21/2011	NON-COMPETING CONTINUATION	$0
2012	2010	CHRISTIAN MEDICAL COLLEGE	POST OFFICE BOX 3	VELLORE		00000			Allergy and Infectious Diseases Research	001	3	12/21/2011	NON-COMPETING CONTINUATION	$0
2012	2009	CHRISTIAN MEDICAL COLLEGE	POST OFFICE BOX 3	VELLORE		00000			Allergy and Infectious Diseases Research	002	2	2/23/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $76,805 )
2011	2011	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	Allergy and Infectious Diseases Research	000	4	2/14/2011	NON-COMPETING CONTINUATION	$70,606
2011	2011	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	Allergy and Infectious Diseases Research	001	4	5/27/2011	NON-COMPETING CONTINUATION	$6,199
														Subtotal = $76,805

Issue Date FY: 2010 ( Subtotal = $77,741 )
2010	2010	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	Allergy and Infectious Diseases Research	000	3	2/10/2010	NON-COMPETING CONTINUATION	$77,741
														Subtotal = $77,741

Issue Date FY: 2009 ( Subtotal = $94,777 )
2009	2009	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	Allergy and Infectious Diseases Research	001	2	6/11/2009	NON-COMPETING CONTINUATION	$7,978
2009	2009	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	Allergy and Infectious Diseases Research	000	2	2/23/2009	NON-COMPETING CONTINUATION	$71,799
2009	2009	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	Allergy and Infectious Diseases Research	002	2	9/23/2009	NON-COMPETING CONTINUATION	$15,000
														Subtotal = $94,777

Issue Date FY: 2008 ( Subtotal = $81,000 )
2008	2008	CHRISTIAN MEDICAL COLLEGE	POST OFFICE BOX 3	VELLORE		00000			Allergy and Infectious Diseases Research	000	1	3/4/2008	NEW	$81,000
														Subtotal = $81,000

Grand Total All Awards = $330,323

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TRANSMISSION DYNAMICS OF CRYPTOSPORIDIAL INFECTIONS IN INDIA

Award Number: R01AI075452

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2008

PERIOD OF PERFORMANCE END DATE: 02/29/2012

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