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Vector and Host Contributions to the Regulation of E. chaffeensis Gene

Award Number: R01AI070908
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2007
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Vector and Host Contributions to the Regulation of E. chaffeensis Gene - PROJECT SUMMARY: Rickettsial diseases caused by the Anaplasmataceae family pathogens of the genera Ehrlichia and Anaplasma remain a growing public health concern for over three decades and are also the second leading cause of tick- borne human infections in the USA and many parts of the world. Despite the complex cellular environments of arthropods and vertebrates having sophisticated systems of defense, the Anaplasmataceae pathogens evolved strategies to evade host clearance. Our prior studies demonstrated that the differential expression in vertebrate and tick cells alters host responses leading to variations in vertebrate host clearance/persistence. The central hypothesis of our competing renewal application remains that E. chaffeensis differentially regulates its gene expression in response to host cell environmental signals and that the host cell-specific gene expression is essential for pathogen’s continued survival in vertebrate and tick cell environments. We have made substantial progress in addressing the three specific aims of the previous funded project. The progress from the prior funded cycle included numerous peer-reviewed publications, which paved the way for additional exciting new directions for this proposed competing renewal application. Goals set for the three new specific aims of this renewal application have a strong premise, as supported with published research results and with additional unpublished preliminary data. The extensive novel data generated with the previous R01 grant support formed a strong foundation for the following proposed three specific aims of this renewal application. 1) Characterize sequence-specific DNA binding proteins (DBPs) in E. chaffeensis impacting RNA polymerase function in support of understanding the pathogen’s host- specific differential gene expression. 2) Characterize the functional significance of genes identified as essential for E. chaffeensis in vivo growth. 3) Mutagenesis and in vivo screening in defining genomic regions critical for the bacterial pathogenesis in vertebrate and tick hosts. The proposed specific aims are a logical extension of the substantial progress we have made during the previous funding cycle. The project goals have a strong scientific premise, as they are supported with the research data reported in many peer-reviewed publications and with the inclusion of additional preliminary data.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Allergy and Infectious Diseases Research	000	14	6/9/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Allergy and Infectious Diseases Research	002	14	12/21/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$589,348
2024	2022	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	001	13	12/21/2023	NON-COMPETING CONTINUATION	-$536,311
2024	2021	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	12	12/21/2023	NON-COMPETING CONTINUATION	-$53,037
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $545,563 )
2023	2023	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Allergy and Infectious Diseases Research	001	14	7/6/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$545,563
2023	2022	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	13	7/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $545,563

Issue Date FY: 2022 ( Subtotal = $536,311 )
2022	2022	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	13	6/23/2022	NON-COMPETING CONTINUATION	$536,311
														Subtotal = $536,311

Issue Date FY: 2021 ( Subtotal = $536,311 )
2021	2021	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	12	7/8/2021	NON-COMPETING CONTINUATION	$536,311
														Subtotal = $536,311

Issue Date FY: 2020 ( Subtotal = $536,311 )
2020	2020	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	002	11	7/6/2020	NON-COMPETING CONTINUATION	$536,311
2020	2019	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	001	10	2/3/2020	COMPETING CONTINUATION	$3,225
2020	2017	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	9	2/3/2020	NON-COMPETING CONTINUATION	-$3,225
														Subtotal = $536,311

Issue Date FY: 2019 ( Subtotal = $536,311 )
2019	2019	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	001	10	7/8/2019	COMPETING CONTINUATION	$536,311
2019	2017	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	9	6/28/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $536,311

Issue Date FY: 2017 ( Subtotal = $441,044 )
2017	2017	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	9	7/5/2017	NON-COMPETING CONTINUATION	$441,044
														Subtotal = $441,044

Issue Date FY: 2016 ( Subtotal = $441,044 )
2016	2016	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	8	7/20/2016	NON-COMPETING CONTINUATION	$441,044
														Subtotal = $441,044

Issue Date FY: 2015 ( Subtotal = $441,044 )
2015	2015	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	7	7/20/2015	NON-COMPETING CONTINUATION	$441,044
														Subtotal = $441,044

Issue Date FY: 2014 ( Subtotal = $441,044 )
2014	2014	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	6	7/31/2014	COMPETING CONTINUATION	$441,044
														Subtotal = $441,044

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2012	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	5	8/9/2013	NON-COMPETING CONTINUATION	$0
2013	2012	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	001	5	8/22/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $357,737 )
2012	2012	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	001	5	5/29/2012	NON-COMPETING CONTINUATION	$35,773
2012	2012	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	5	11/25/2011	NON-COMPETING CONTINUATION	$321,964
														Subtotal = $357,737

Issue Date FY: 2011 ( Subtotal = $357,737 )
2011	2011	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	4	11/5/2010	NON-COMPETING CONTINUATION	$325,215
2011	2011	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	001	4	6/8/2011	NON-COMPETING CONTINUATION	$32,522
														Subtotal = $357,737

Issue Date FY: 2010 ( Subtotal = $423,267 )
2010	2010	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	002	3	5/3/2010	NON-COMPETING CONTINUATION	$32,850
2010	2010	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	001	3	4/19/2010	SUPPLEMENT FOR EXPANSION	$61,917
2010	2010	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	3	11/12/2009	NON-COMPETING CONTINUATION	$328,500
														Subtotal = $423,267

Issue Date FY: 2009 ( Subtotal = $365,000 )
2009	2009	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	001	2	6/9/2009	NON-COMPETING CONTINUATION	$36,500
2009	2009	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	2	11/13/2008	NON-COMPETING CONTINUATION	$328,500
														Subtotal = $365,000

Issue Date FY: 2008 ( Subtotal = $365,000 )
2008	2008	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Allergy and Infectious Diseases Research	000	1	12/5/2007	NEW	$365,000
														Subtotal = $365,000

Grand Total All Awards = $6,323,724

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Vector and Host Contributions to the Regulation of E. chaffeensis Gene

Award Number: R01AI070908

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2007

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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