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Allergic inflammation and Transcriptional Regulation in Th9 cells

Award Number: R01AI057459
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY – Regulation of Allergic inflammation by IL-9-secreting T cells Interleukin-9 (IL-9) is a pleuripotent cytokine that leads to altered gene expression and cellular function in hematopoietic and structural cell populations. IL-9 is most efficiently produced by innate lymphoid cells, and a specialized subset of T helper cells termed Th9 cells. Importantly, IL-9 has a role, in both humans and mouse models, in asthma, food allergy, ulcerative colitis, and anti-tumor immunity. In the previous funding period of this grant we have made considerable progress in understanding the regulation of the Il9 gene and the transcription factors that are involved in controlling Il9 gene expression. As we defined systems for best analyzing IL-9-secreting T cells in vivo, we observed that in a model of chronic allergen exposure, IL-9- producing CD4+ T cells were in the tissue resident memory (Trm) population. We further observed that the IL- 9-secreting Trm population was stable in the absence of allergen exposure and was instrumental in mediating the inflammatory response to allergen challenge after a period of ‘rest’ from allergen exposure. Blocking IL-9 during this post-rest challenge significantly diminished the inflammatory response. In this renewal application, we will define the identity of the IL-9-secreting T cells, determine the transcription factors that are required for their development, and identify the cytokines that are important for their development, maintenance, and effector function. As the CD4+ Trm population in allergic inflammation has not been characterized and this population is likely important in the context of intermittent allergen exposure as occurs in seasonal allergies, the proposed studies could have a foundational impact on understanding how CD4+ Trm impact allergic disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $508,405 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Allergy and Infectious Diseases Research	000	18	10/23/2023	NON-COMPETING CONTINUATION	$508,405
														Subtotal = $508,405

Issue Date FY: 2023 ( Subtotal = $564,894 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Allergy and Infectious Diseases Research	000	17	10/19/2022	NON-COMPETING CONTINUATION	$564,894
														Subtotal = $564,894

Issue Date FY: 2022 ( Subtotal = $564,894 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Allergy and Infectious Diseases Research	000	16	11/4/2021	NON-COMPETING CONTINUATION	$564,894
														Subtotal = $564,894

Issue Date FY: 2021 ( Subtotal = $563,908 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Allergy and Infectious Diseases Research	001	15	11/16/2020	COMPETING CONTINUATION	$563,908
2021	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Allergy and Infectious Diseases Research	002	14	7/22/2021	NON-COMPETING CONTINUATION	$0
2021	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Allergy and Infectious Diseases Research	000	14	11/5/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $563,908

Issue Date FY: 2019 ( Subtotal = $463,320 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Allergy and Infectious Diseases Research	000	14	11/21/2018	NON-COMPETING CONTINUATION	$463,320
														Subtotal = $463,320

Issue Date FY: 2018 ( Subtotal = $463,320 )
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Allergy and Infectious Diseases Research	000	13	11/3/2017	NON-COMPETING CONTINUATION	$463,320
														Subtotal = $463,320

Issue Date FY: 2017 ( Subtotal = $463,320 )
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Allergy and Infectious Diseases Research	000	12	11/21/2016	NON-COMPETING CONTINUATION	$463,320
														Subtotal = $463,320

Issue Date FY: 2016 ( Subtotal = $463,320 )
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	001	11	1/20/2016	COMPETING CONTINUATION	$0
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	11	12/11/2015	COMPETING CONTINUATION	$463,320
														Subtotal = $463,320

Issue Date FY: 2014 ( Subtotal = $381,150 )
2014	2014	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	10	4/14/2014	NON-COMPETING CONTINUATION	$381,150
														Subtotal = $381,150

Issue Date FY: 2013 ( Subtotal = $358,281 )
2013	2013	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	9	4/15/2013	NON-COMPETING CONTINUATION	$343,035
2013	2013	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	001	9	6/7/2013	NON-COMPETING CONTINUATION	$15,246
														Subtotal = $358,281

Issue Date FY: 2012 ( Subtotal = $381,150 )
2012	2012	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	8	4/16/2012	NON-COMPETING CONTINUATION	$381,150
														Subtotal = $381,150

Issue Date FY: 2011 ( Subtotal = $381,150 )
2011	2011	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	7	4/22/2011	NON-COMPETING CONTINUATION	$346,500
2011	2011	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	001	7	6/6/2011	NON-COMPETING CONTINUATION	$34,650
														Subtotal = $381,150

Issue Date FY: 2010 ( Subtotal = $416,707 )
2010	2010	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	6	4/28/2010	COMPETING CONTINUATION	$385,000
2010	2009	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	002	5	4/28/2010	NON-COMPETING CONTINUATION	$0
2010	2009	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	001	5	4/28/2010	NON-COMPETING CONTINUATION	$31,707
														Subtotal = $416,707

Issue Date FY: 2009 ( Subtotal = $317,071 )
2009	2009	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	001	5	6/5/2009	NON-COMPETING CONTINUATION	$31,707
2009	2009	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	5	2/11/2009	NON-COMPETING CONTINUATION	$285,364
														Subtotal = $317,071

Issue Date FY: 2008 ( Subtotal = $317,071 )
2008	2008	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	4	2/13/2008	NON-COMPETING CONTINUATION	$317,071
														Subtotal = $317,071

Issue Date FY: 2007 ( Subtotal = $323,212 )
2007	2007	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	3	3/2/2007	NON-COMPETING CONTINUATION	$323,212
														Subtotal = $323,212

Issue Date FY: 2006 ( Subtotal = $332,865 )
2006	2006	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	2	3/2/2006	NON-COMPETING CONTINUATION	$332,865
														Subtotal = $332,865

Issue Date FY: 2005 ( Subtotal = $340,875 )
2005	2005	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Allergy and Infectious Diseases Research	000	1	3/10/2005	NEW	$340,875
														Subtotal = $340,875

Grand Total All Awards = $7,604,913

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Allergic inflammation and Transcriptional Regulation in Th9 cells

Award Number: R01AI057459

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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