Sunday, May 11, 2025 5/11/2025

Field Studies of Cryptosporidiosis in Bangladesh

Award Number: R01AI043596
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Field Studies of Cryptosporidiosis in Bangladesh - Project Summary Introduction: Immunity to Cryptosporidium diarrhea develops by four years of age in children living in an area of high transmission intensity. Hypothesis: Children upon repeated infection develop immunity in part via a unique repertoire and functional capacity of antibodies against the parasite due to Tfh cell activation. Significance: The proposal will provide insight into the human immune system response to intraepithelial parasitism and inform vaccine design to prevent the estimated 7 million Cryptosporidium-attributable cases of diarrhea, 200,000 deaths annually in children under the age of 2 years. Investigators: The application is the product of 25 years of collaboration between Drs. Petri & Gilchrist at the University of Virginia and Dr. Haque at icddr,b in Bangladesh, joined by Dr. Campo at Antigen Discovery. Innovation: The hypothesis is innovative as it challenges the existing paradigm that humoral immunity is unimportant in immunity to cryptosporidiosis. Innovative approaches include the longitudinal study of infection of children in an area of high transmission intensity, probing humoral immunity with a parasite protein microarray and functional measures, and activation-induced marker (AIM) assays of Tfh function during active infection. Progress over the last 5 years of funding: 51 papers published, demonstrating the acquisition of immunity to cryptosporidiosis in children living in a high transmission area, identification of 7/233 parasite antigens recognized by immune sera as associated with protection, discovery of protection from both malnutrition and cryptosporidiosis with an anti-parasite Cp23 protein antibody response, identification of human genetic susceptibility via a polymorphism in protein kinase C, evidence of parasite genotype-specific antibody responses, the importance of the microbiome and prior antibiotics, and transmission during monsoon and within households. Approach: Specific Aim 1 (ADI & UVA): In Depth Characterization of Cryptosporidium Antigens Recognized by the Humoral Immune Response as Children Develop Immunity from Repeated Infections. Specific Aim 2 (UVA & ADI): Functional Characterization of Anti-Cryptosporidium Antibodies. Specific Aim 3 (UVA & icddr,b): Role of T follicular helper (Tfh) Cells in Induction of the Antibody Response. Environment: The University of Virginia is internationally recognized as a center for Global Health research, the icddr,b is the premier institution for the study of diarrheal diseases in low and middle income countries, and ADI Inc. is a leader in protein microarrays.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	25	2/24/2025	COMPETING CONTINUATION	$194,181
2025	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	24	2/24/2025	NON-COMPETING CONTINUATION	-$194,181
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $512,744 )
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	25	5/31/2024	COMPETING CONTINUATION	$464,543
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	003	25	9/6/2024	COMPETING CONTINUATION	$0
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	002	25	9/3/2024	COMPETING CONTINUATION	$48,201
2024	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	24	6/4/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $512,744

Issue Date FY: 2023 ( Subtotal = $382,486 )
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	24	3/1/2023	NON-COMPETING CONTINUATION	$382,486
														Subtotal = $382,486

Issue Date FY: 2022 ( Subtotal = $372,032 )
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	23	3/4/2022	NON-COMPETING CONTINUATION	$372,032
														Subtotal = $372,032

Issue Date FY: 2021 ( Subtotal = $384,032 )
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	22	2/3/2021	NON-COMPETING CONTINUATION	$384,032
														Subtotal = $384,032

Issue Date FY: 2020 ( Subtotal = $377,960 )
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	21	2/27/2020	NON-COMPETING CONTINUATION	$377,960
2020	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	002	20	4/9/2020	COMPETING CONTINUATION	$109,285
2020	2017	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	19	4/9/2020	NON-COMPETING CONTINUATION	-$109,285
														Subtotal = $377,960

Issue Date FY: 2019 ( Subtotal = $408,424 )
2019	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	20	3/19/2019	COMPETING CONTINUATION	$408,424
2019	2017	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	19	3/18/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $408,424

Issue Date FY: 2017 ( Subtotal = $351,419 )
2017	2017	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	008	19	8/10/2017	NON-COMPETING CONTINUATION	$351,419
2017	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	007	18	6/16/2017	EXTENSION WITH OR WITHOUT FUNDS	-$19,427
2017	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	18	2/16/2017	EXTENSION WITH OR WITHOUT FUNDS	$188,385
2017	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	003	18	4/28/2017	EXTENSION WITH OR WITHOUT FUNDS	$168,958
2017	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	005	18	6/15/2017	EXTENSION WITH OR WITHOUT FUNDS	-$168,958
2017	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	006	17	6/16/2017	NON-COMPETING CONTINUATION	$19,427
2017	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	002	17	4/28/2017	NON-COMPETING CONTINUATION	-$19,427
2017	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	17	2/16/2017	NON-COMPETING CONTINUATION	-$188,385
2017	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	004	17	6/15/2017	NON-COMPETING CONTINUATION	$19,427
														Subtotal = $351,419

Issue Date FY: 2016 ( Subtotal = $351,396 )
2016	2016	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	18	8/8/2016	EXTENSION WITH OR WITHOUT FUNDS	$351,396
														Subtotal = $351,396

Issue Date FY: 2015 ( Subtotal = $351,395 )
2015	2015	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	17	7/23/2015	NON-COMPETING CONTINUATION	$351,395
														Subtotal = $351,395

Issue Date FY: 2014 ( Subtotal = $350,757 )
2014	2014	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	16	7/29/2014	NON-COMPETING CONTINUATION	$350,757
														Subtotal = $350,757

Issue Date FY: 2013 ( Subtotal = $356,892 )
2013	2013	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	15	9/20/2013	COMPETING CONTINUATION	$356,892
2013	2012	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	14	9/20/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $356,892

Issue Date FY: 2012 ( Subtotal = $248,597 )
2012	2012	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	14	1/26/2012	NON-COMPETING CONTINUATION	$248,597
														Subtotal = $248,597

Issue Date FY: 2011 ( Subtotal = $248,523 )
2011	2011	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	13	6/3/2011	NON-COMPETING CONTINUATION	$22,593
2011	2011	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	13	12/15/2010	NON-COMPETING CONTINUATION	$225,930
														Subtotal = $248,523

Issue Date FY: 2010 ( Subtotal = $251,107 )
2010	2010	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	12	12/18/2009	NON-COMPETING CONTINUATION	$228,280
2010	2010	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	12	5/10/2010	NON-COMPETING CONTINUATION	$22,827
														Subtotal = $251,107

Issue Date FY: 2009 ( Subtotal = $253,439 ) (Continued on the next page)
2009	2009	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	11	7/16/2009	NON-COMPETING CONTINUATION	$25,344
Grand Total All Awards = $7,106,011

Page 1 of 2 (71 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Field Studies of Cryptosporidiosis in Bangladesh

Award Number: R01AI043596

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer