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Field Studies of Cryptosporidiosis in Bangladesh

Award Number: R01AI043596
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Introduction: We propose to design a vaccine for Cryptosporidia by identifying antigenic targets of the parasite that are neutralized by mucosal IgA, are antigenically conserved, recognized by cell mediated immunity (CMI), and associated with protection of infants. Hypothesis: Protection from Cryptosporidia is via anti-IgA mucosal antibodies against surface-exposed antigens that provide broadly-neutralizing prevention of infection, and via cell mediated immune responses required for resolution of infection. Premise: A vaccine can be rationally designed by identifying microbial antigens that are broadly conserved and recognized by immune responses associated with protection. Significance: Cryptosporidiosis is a top 10 cause of diarrhea in the 1st year of life in low and middle-income countries. In North America it is the leading etiology of water-borne diarrhea, a biodefense category B agent, and cause of chronic diarrhea in AIDS. Investigators: The multiple PIs Drs. Petri and Gilchrist at the University of Virginia, and the foreign site lead Dr. Haque at icddr,b, have collaborated on enteric parasites for 25 years. For Cryptosporidia they have discovered in infants acquired immunity associated with a mucosal IgA response, and through genome resequencing conserved antigens. They are joined by Dr. Campo of Antigen Discovery (ADI) who brings an eminently successful track record in use of microbial proteome arrays for antigen discovery. Innovation: The identification of IgA acquired immune responses associated with protection, and application of a proteome microarray to identify targets of mucosal IgA are ground-breaking in Cryptosporidiosis Approach: There are three Specific Aims: Specific Aim 1. Assess the natural history of Cryptosporidiosis through age 5 in children in an urban slum of Dhaka, Bangladesh. Specific Aim 2: Measure the duration and magnitude of passive and active immunity associated with IgA against the parasite Cp23 antigen. Specific Aim 3: Discover antigens for a broadly neutralizing vaccine. Environment: Key to success are the complementary expertise of the team at the University of Virginia in molecular parasitology, at icddr,b in clinical investigation, and at ADI in antigen discovery. This robust collaboration has led to the substantial published and preliminary data presented in the proposal.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $382,486 )
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	24	3/1/2023	NON-COMPETING CONTINUATION	$382,486
														Subtotal = $382,486

Issue Date FY: 2022 ( Subtotal = $372,032 )
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	23	3/4/2022	NON-COMPETING CONTINUATION	$372,032
														Subtotal = $372,032

Issue Date FY: 2021 ( Subtotal = $384,032 )
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	22	2/3/2021	NON-COMPETING CONTINUATION	$384,032
														Subtotal = $384,032

Issue Date FY: 2020 ( Subtotal = $377,960 )
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	21	2/27/2020	NON-COMPETING CONTINUATION	$377,960
2020	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	002	20	4/9/2020	COMPETING CONTINUATION	$109,285
2020	2017	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	19	4/9/2020	NON-COMPETING CONTINUATION	-$109,285
														Subtotal = $377,960

Issue Date FY: 2019 ( Subtotal = $408,424 )
2019	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	20	3/19/2019	COMPETING CONTINUATION	$408,424
2019	2017	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	19	3/18/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $408,424

Issue Date FY: 2017 ( Subtotal = $351,419 )
2017	2017	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	008	19	8/10/2017	NON-COMPETING CONTINUATION	$351,419
2017	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	003	18	4/28/2017	EXTENSION WITH OR WITHOUT FUNDS	$168,958
2017	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	005	18	6/15/2017	EXTENSION WITH OR WITHOUT FUNDS	-$168,958
2017	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	007	18	6/16/2017	EXTENSION WITH OR WITHOUT FUNDS	-$19,427
2017	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	18	2/16/2017	EXTENSION WITH OR WITHOUT FUNDS	$188,385
2017	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	004	17	6/15/2017	NON-COMPETING CONTINUATION	$19,427
2017	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	002	17	4/28/2017	NON-COMPETING CONTINUATION	-$19,427
2017	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	17	2/16/2017	NON-COMPETING CONTINUATION	-$188,385
2017	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	006	17	6/16/2017	NON-COMPETING CONTINUATION	$19,427
														Subtotal = $351,419

Issue Date FY: 2016 ( Subtotal = $351,396 )
2016	2016	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	18	8/8/2016	EXTENSION WITH OR WITHOUT FUNDS	$351,396
														Subtotal = $351,396

Issue Date FY: 2015 ( Subtotal = $351,395 )
2015	2015	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	17	7/23/2015	NON-COMPETING CONTINUATION	$351,395
														Subtotal = $351,395

Issue Date FY: 2014 ( Subtotal = $350,757 )
2014	2014	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	16	7/29/2014	NON-COMPETING CONTINUATION	$350,757
														Subtotal = $350,757

Issue Date FY: 2013 ( Subtotal = $356,892 )
2013	2013	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	15	9/20/2013	COMPETING CONTINUATION	$356,892
2013	2012	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	14	9/20/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $356,892

Issue Date FY: 2012 ( Subtotal = $248,597 )
2012	2012	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	14	1/26/2012	NON-COMPETING CONTINUATION	$248,597
														Subtotal = $248,597

Issue Date FY: 2011 ( Subtotal = $248,523 )
2011	2011	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	13	12/15/2010	NON-COMPETING CONTINUATION	$225,930
2011	2011	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	13	6/3/2011	NON-COMPETING CONTINUATION	$22,593
														Subtotal = $248,523

Issue Date FY: 2010 ( Subtotal = $251,107 )
2010	2010	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	12	5/10/2010	NON-COMPETING CONTINUATION	$22,827
2010	2010	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	12	12/18/2009	NON-COMPETING CONTINUATION	$228,280
														Subtotal = $251,107

Issue Date FY: 2009 ( Subtotal = $253,439 )
2009	2009	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	11	12/25/2008	NON-COMPETING CONTINUATION	$228,095
2009	2009	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	001	11	7/16/2009	NON-COMPETING CONTINUATION	$25,344
														Subtotal = $253,439

Issue Date FY: 2008 ( Subtotal = $266,533 )
2008	2008	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	10	12/17/2007	COMPETING CONTINUATION	$266,533
														Subtotal = $266,533

Issue Date FY: 2007 ( Subtotal = $212,461 )
2007	2007	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	9	12/20/2006	NON-COMPETING CONTINUATION	$212,461
														Subtotal = $212,461

Issue Date FY: 2006 ( Subtotal = $218,806 )
2006	2006	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Allergy and Infectious Diseases Research	000	8	1/19/2006	NON-COMPETING CONTINUATION	$218,806
														Subtotal = $218,806

Issue Date FY: 2005 ( Subtotal = $223,838 ) (Continued on the next page)
Grand Total All Awards = $6,593,267

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Field Studies of Cryptosporidiosis in Bangladesh

Award Number: R01AI043596

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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