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A Pragmatic Clinical Trial to Improve Screening for Cognitive Impairment in Older Adults with Diabetes

Award Number: R01AG103426
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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A Pragmatic Clinical Trial to Improve Screening for Cognitive Impairment in Older Adults with Diabetes - Project Abstract In the United States, more than 17 million adults aged 65 years and older live with diabetes mellitus, a chronic condition that significantly increases the risk of Alzheimer’s disease and related dementias (ADRD). In older adults with diabetes, cognitive impairment and ADRD is a major risk factor for complications, including severe hypoglycemia, falls, fractures, frailty, and mortality. Although cognitive screening is recommended to reduce overtreatment and complications, the rates of screening in older adults with diabetes are unknown. Moreover, simple approaches that can be scaled to improve population-wide screening are lacking. In this project, we propose to leverage advanced natural language processing (NLP) and large language models (LLMs) to develop and validate novel tools for identifying cognitive and ADRD screening in electronic health record data. We will then conduct a pragmatic trial of a clinical decision support (CDS) intervention to improve geriatric cognitive screening, diagnosis, and management in older adults with comorbid diabetes. As the U.S. population continues to age, the dual burden of age-related cognitive decline/ADRD and diabetes will grow rapidly. Our study will support scalable, system-level interventions to support geriatric screening practices, and ultimately promote healthy aging, prevent injury, and improve quality of life for older adults with comorbid diabetes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $680,637 )
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	1	9/3/2026	NEW	$680,637
														Subtotal = $680,637

Grand Total All Awards = $680,637

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A Pragmatic Clinical Trial to Improve Screening for Cognitive Impairment in Older Adults with Diabetes

Award Number: R01AG103426

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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