Tuesday, November 4, 2025 11/4/2025

Restoring Cognitive Function through Precision Neurostimulation: A Disease-Agnostic Approach Based on Convergent Hippocampal Dynamics.

Award Number: R01AG100834
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2030

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Restoring Cognitive Function through Precision Neurostimulation: A Disease-Agnostic Approach Based on Convergent Hippocampal Dynamics. - PROJECT SUMMARY The hippocampus, a key part of our brain involved in memory and emotional regulation, often malfunctions in many brain disorders, from developmental issues like autism to neurodegenerative diseases such as Alzheimer’s Disease. This dysfunction can severely affect memory, social interactions, and overall quality of life. Traditional treatments usually target specific disease-related changes at the molecular or protein level but have had limited success. Our research aims to revolutionize this approach by focusing on the fundamental brain activity patterns of the hippocampus. We propose that by correcting these disrupted activity patterns, we can improve cognitive function regardless of the disorder’s cause. We will use six models of three common neurological disorders to define similar abnormalities in brain activity across disease groups and examine whether brain stimulation can improve both dynamics and performance in cognitive tests. We will extend this approach with in-silico experiments that will model an extensive range of pathophysiological processes and evaluate many more stimulation parameters than is currently feasible in biological models. Our iterative approach that combines in-vivo and in-silico approaches is poised to accelerate clinical translation of our studies. This new strategy could lead to groundbreaking treatments for a wide range of cognitive issues, potentially benefiting millions of people. By using advanced techniques to understand and address these brain activity disruptions, our work promises to pave the way for innovative therapies and better quality of life for those with cognitive impairments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $547,998 )
2025	2025	THE NEMOURS FOUNDATION	1600 ROCKLAND RD	WILMINGTON	DE	19803	NEW CASTLE	USA	Aging Research	000	1	9/15/2025	NEW	$547,998
														Subtotal = $547,998

Grand Total All Awards = $547,998

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Restoring Cognitive Function through Precision Neurostimulation: A Disease-Agnostic Approach Based on Convergent Hippocampal Dynamics.

Award Number: R01AG100834

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2030

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