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Addressing Alzheimer's Disease and Alzheimer's Disease Related Dementias Needs in Indigenous Populations: The Indigenous Behavioral and Cognitive Symptoms (IBACS) Checklists

Award Number: R01AG100759
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Addressing Alzheimer's Disease and Alzheimer's Disease Related Dementias Needs in Indigenous Populations: The Indigenous Behavioral and Cognitive Symptoms (IBACS) Checklists - Indigenous populations have some of the highest rates of Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD) in the world and typically experience an earlier age of onset. As these rates are expected to increase in the coming decades, significant investments in early detection are urgently needed. Mild behavioral impairment (MBI) and subjective cognitive decline (SCD) in older, cognitively unimpaired adults may represent the earliest stage of incipient dementia. MBI and SCD symptoms checklists could provide Indigenous Nations with important tools for the timely detection of prodromal AD/ADRD that are easily implemented, effective, and culturally safe. The existing MBI and SCD checklists did not take into consideration potential differences in Indigenous perceptions of symptoms deemed clinically concerning. Thus, there is a need to develop a framework to understand the applicability of the current MBI and SCD constructs and develop valid tools to identify MBI and SCD in Indigenous populations, thereby increasing the probability of early diagnosis, preventative interventions, and family education. We propose adapting two checklists for use with Indigenous Nations in North America, specifically, the Mild Behavioral Impairment Checklist (MBI-C) and the Cognitive Change Index (CCI). Our goal is to use our proven mixed-methods framework to understand, adapt, and validate these sensitive and highly regarded clinical tools for detecting behavioral and cognitive symptoms of dementia for Indigenous Nations across North America. Our central hypothesis is that culture drives the interpretation of questions about behavioral and cognitive symptoms of dementia, necessitating adaptations done with consideration of culturally- bound distinctions for the development of reliable and valid Indigenous versions of the MBI-C and CCI questionnaires. The outcome of this project will be the Indigenous MBI-C (IMBIC) and the Indigenous CCI (ICCI), collectively referred to as the Indigenous Behavioral and Cognitive Symptoms (IBACS) Checklists. This project will be done in collaboration with six distinct Tribal research partners in North America. We have established relationships with all of our research partners; four of the six communities are currently engaged in ongoing research projects with MPIs Jacklin, Gleason, and Parker. Aims 1 and 2 focus on the adaptation and validation of the checklists. Exploratory Aim 3 focuses on clarifying community-related brain health promotion and resilience factors and existing resources supporting implementation of the IBACS Checklists. This work is grounded in a community-based participatory research model centered in Indigenous methodologies. This proposal responds to a high-priority area identified by the National Institute on Aging to adapt assessment tools for use with high- risk population sub-groups to address differences in AD/ADRD outcomes. Our results will empower Indigenous populations to lead dementia risk detection initiatives, opening avenues for representative clinical research. Without these germinal efforts, Indigenous populations will remain under-included in clinical research, further perpetuating differences in AD/ADRD outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $4,010,962 )
2026	2026	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Aging Research	000	1	8/24/2026	NEW	$4,010,962
														Subtotal = $4,010,962

Grand Total All Awards = $4,010,962

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Addressing Alzheimer's Disease and Alzheimer's Disease Related Dementias Needs in Indigenous Populations: The Indigenous Behavioral and Cognitive Symptoms (IBACS) Checklists

Award Number: R01AG100759

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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