Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Whole-Organism and Organ-Specific Biological Aging Clocks in Response to Calorie Restriction Interventions

Award Number: R01AG094747
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2031

Group Awards By:

View Award Description

Whole-Organism and Organ-Specific Biological Aging Clocks in Response to Calorie Restriction Interventions - Abstract Age is among the strongest risk factors for cardiometabolic disorders. Calorie restriction is the most potent, non-pharmacological intervention that increases lifespan with reduced risks of aging-related disorders. However, the molecular basis of the beneficial effects of calorie restriction on intrinsic processes of aging ─ biological aging, remains poorly understood. Emerging evidence indicates that profiling blood proteome by novel technologies provides new insights into intrinsic biological aging; and several recent studies have identified proteome-derived clocks which could accurately predict whole- body (organismal) and organ-specific biological aging. The overarching goal of our study is to investigate long-term changes in blood proteomic whole-body and organ-specific biological aging clocks in response to calorie restriction interventions. Built upon two long-term calorie restriction intervention studies ─ the POUNDS LOST trial and the CENTRAL trial, we will identify blood proteomic whole-body (organismal) and organ-specific aging clocks; and analyze their dynamic changes in response to calorie restriction interventions (Aim 1). We will also examine relations of baseline levels and dynamic changes (up to 2 years during interventions and 10-year post-intervention follow-up) of blood proteomic whole-body and organ-specific aging clocks with changes in cardiometabolic outcomes (Aim 2). In addition, we will examine relations of dynamic changes in blood proteomic whole-body and organ-specific aging clocks with calorie restriction-induced metabolic adaptation; and assess the mediation effects of metabolic adaptation in the relations between proteomic aging clocks and cardiometabolic changes (Aim 3). Moreover, we will examine relations of blood proteomic whole-body and organ-specific aging clocks with epigenetic aging clocks, and multi-clock interactions on cardiometabolic changes (Aim 4). Our project is the first and largest of its kind investigating long-term changes in blood whole-body and organ-specific proteomic aging clocks in response to calorie restriction interventions. Results from our study will provide new insight into molecular mechanisms underlying the beneficial effects of calorie restriction on intrinsic biological aging; and identify novel modifiable targets for precision anti- senescence interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $616,284 )
2026	2026	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Aging Research	001	1	7/29/2026	SUPPLEMENT FOR EXPANSION	$58,773
2026	2026	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Aging Research	000	1	7/20/2026	NEW	$557,511
														Subtotal = $616,284

Grand Total All Awards = $616,284

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Whole-Organism and Organ-Specific Biological Aging Clocks in Response to Calorie Restriction Interventions

Award Number: R01AG094747

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2031

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer