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Longitudinal Impact of Clonal Hematopoiesis on Aging Outcomes and Risk Prediction in the REasons for Geographic and Racial Differences in Stroke Study

Award Number: R01AG094122
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2026
PERIOD OF PERFORMANCE END DATE: 11/30/2030

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Longitudinal Impact of Clonal Hematopoiesis on Aging Outcomes and Risk Prediction in the REasons for Geographic and Racial Differences in Stroke Study - PROJECT SUMMARY Clonal hematopoiesis (CH) refers to abnormal expansion of hematopoietic cell clones in the absence of hematologic abnormalities. Though CH was initially identified as recurrent somatic mutations in those with myeloid malignancies, these mutations are identified in apparently healthy individuals and are especially common in older individuals. Clonal hematopoiesis has only been recognized as an entity for the past ~10 years, and we have a poor understanding of the risk factors for, evolution of, and consequences of CH in a broad representative population. We propose to measure CH in the 30,239 participants in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study at baseline and ~9 years later. By measuring CH over time, we will gain insights into clonal dynamics and how CH changes over time as well as potential driving factors for CH which may be amenable to interventions. Our aims are to: 1. Define the baseline risk factors of CH in the REGARDS cohort including germline genetics. 2. Prospectively define the risk factors for CH incidence and progression in the REGARDS cohort 3. Establish the contribution and causality of CH to adverse age-related outcomes including survival, cognition, coronary heart disease, stroke, heart failure, cancer, and incident cardiovascular risk factors. The biracial and geographically diverse REGARDS cohort offers an unrivaled opportunity to determine novel insights into the etiology, epidemiology, and consequences of CH.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $664,971 )
2026	2026	UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE	85 S PROSPECT STREET	BURLINGTON	VT	05405	CHITTENDEN	USA	Aging Research	000	1	2/5/2026	NEW	$664,971
														Subtotal = $664,971

Grand Total All Awards = $664,971

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Longitudinal Impact of Clonal Hematopoiesis on Aging Outcomes and Risk Prediction in the REasons for Geographic and Racial Differences in Stroke Study

Award Number: R01AG094122

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2026

PERIOD OF PERFORMANCE END DATE: 11/30/2030

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