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Testing the Efficacy of a Personalized Multi-Domain Behavioral Intervention for Alzheimer's Disease and Related Dementias Risk Reduction in Midlife

Award Number: R01AG093970
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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Testing the Efficacy of a Personalized Multi-Domain Behavioral Intervention for Alzheimer's Disease and Related Dementias Risk Reduction in Midlife - PROJECT ABSTRACT This Stage II behavioral intervention development project will examine the efficacy of a multi-domain health behavior intervention for primary prevention of Alzheimer’s disease and related dementias (ADRD) in middle age. Modifiable risk factors, including physical activity, diet, diabetes, hypertension, sleep quality, and cognitive activity, are associated with lower risk of ADRD. However, population engagement in positive health behaviors is low, as is adherence to large, multi-domain prevention trial protocols. This raises concern about generating and sustaining health behavior change over the interval, likely years, needed to prevent ADRD. Our 8-week, remotely-delivered TEACH intervention (Tailored Education for Aging and Cognitive Health) uses the science of behavior change, grounded in the Health Belief Model, to promote multi-domain health behavior change. TEACH includes assessment of and personalized education about seven intrapersonal health belief factors that moderate behavior change and a problem-solving method for setting actionable goals within the health belief framework. TEACH was specifically designed to promote maintenance, not just initiation, of health behaviors that reduce risk for ADRD. The proposed project will include a randomized controlled trial (N=100 per arm; 1:1 allocation) to examine the efficacy of TEACH versus basic health education alone at end of treatment (8 weeks) and 4- and 12-month follow-up. We will examine the efficacy of the intervention on a multidomain behavioral composite score and individual health behaviors related to dementia risk (Aim 1) as well as biological outcomes including metabolic syndrome severity and a proteomic dementia risk score validated for midlife adults (Aim 2). We will also examine behavioral mediators of treatment effects on biological outcomes (how the intervention works) and its possible moderators (who benefits the most; Aim 3), which will be used to inform future implementation studies. This innovative intervention has both scientific and practical applications in promoting the long-term maintenance of health behaviors important for primary prevention of ADRD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $715,386 )
2026	2026	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Aging Research	000	1	9/17/2026	NEW	$715,386
														Subtotal = $715,386

Grand Total All Awards = $715,386

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Testing the Efficacy of a Personalized Multi-Domain Behavioral Intervention for Alzheimer's Disease and Related Dementias Risk Reduction in Midlife

Award Number: R01AG093970

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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