Tuesday, January 6, 2026 1/6/2026

Activity-dependent astrocyte glucose dynamics regulate hippocampal neurogenesis

Award Number: R01AG091353
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2029

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Activity-dependent astrocyte glucose dynamics regulate hippocampal neurogenesis - Abstract Newly generated neurons in adult hippocampal neurogenesis face a critical survival phase immediately after birth, heavily reliant on glucose-derived energy. However, the competitive and activity-dependent acquisition and utilization of this fuel remains poorly understood. This study utilizes advanced tools to decipher how hippocampal neural activity governs astrocyte glucose metabolism and lactate production, ultimately dictating the fate of young newborn neurons. Three specific aims guide our investigation. Aim 1 pinpoints specific hippocampal interneurons that regulate astrocyte glucose uptake and metabolism, forging a crucial link between neuronal circuit activity and activity-dependent astrocyte glucose dynamics. Aim 2 unravels the mechanisms behind lactate's role in newborn neuron survival, determining whether it directly fuels them or activates critical signaling pathways. Aim 3, inspired by observations of impaired neurogenesis and glucose metabolism in Alzheimer's disease, investigates whether astrocytes hold the key to this decline. Their lactate dynamics and associated key metabolic enzymes for lactate and glucose will be analyzed for defects. Glucose uptake will be genetically manipulated to definitively establish its role. By uncovering the interplay between neuronal activity, astrocyte metabolism, and lactate, this project aims to examine the underlying mechanisms of activity-induced adult neurogenesis in health and disease. It paves the way for novel neuroimaging techniques and offers new insights for therapeutic development in neurodegenerative disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $619,578 )
2026	2026	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Aging Research	000	2	12/23/2025	NON-COMPETING CONTINUATION	$619,578
														Subtotal = $619,578

Issue Date FY: 2025 ( Subtotal = $688,419 )
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Aging Research	001	1	12/13/2024	NEW	$0
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	W5510 FRANKS MELVILLE MEMORIAL LIBRARY	STONY BROOK	NY	11794	SUFFOLK	USA	Aging Research	000	1	12/12/2024	NEW	$688,419
														Subtotal = $688,419

Grand Total All Awards = $1,307,997

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Activity-dependent astrocyte glucose dynamics regulate hippocampal neurogenesis

Award Number: R01AG091353

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2029

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