Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Lifecourse sleep, cognitive decline and risk of Alzheimer's disease: a pooled cohort study.

Award Number: R01AG083836
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2029

Group Awards By:

View Award Description

Lifecourse sleep, cognitive decline and risk of Alzheimer's disease: a pooled cohort study. - PROJECT SUMMARY/ABSTRACT Mounting evidence from our team and others suggests a potential bi-directional relationship between sleep and Alzheimer's disease and related dementias (ADRD) in older adults, in which sleep disturbances precede clinical ADRD, in addition to commonly occurring after disease onset. This bi-directional relationship has important implications for the early intervention of ADRD, yet it remains debatable whether sleep disturbance is a prodromal or modifiable risk factor of ADRD. Research to disentangle the role of sleep in ADRD requires the use of a life course approach to address the directionality of the association, particularly given the long neurodegenerative processes leading to ADRD before symptoms onset and the large variations in sleep disturbances across the life course. Our long-term goal is to develop preventive strategies for ADRD by addressing the role of sleep disturbances across the life course. The objective of this proposal is to determine the effects of objective and subjective sleep disturbances on age-related cognitive decline and risk of ADRD across the life course in diverse populations, and to elucidate mechanistic pathways contributing to this association at different stages of life. Our central hypothesis is that objective and subjective sleep disturbances over the life course are associated with life-course cognitive trajectories and risk of ADRD, with varying magnitude and different underlying pathways for each stage of life. We have an unprecedented opportunity to leverage data from six well-characterized longitudinal cohorts, two with 40-50% Black or Mexican American participants, to create a synthesized diverse cohort of ~35,000 (age 30-104) adults with objective (polysomnography and actigraphy) and subjective sleep measures, and cognition assessed regularly spanning up to 60 years. We will also perform replication analysis using data from the UK Biobank, a study of 500,000 UK adults aged 40-84 years. By applying an innovative life course approach both in the synthesized and each individual cohort, we will address the following aims: 1) Identify age trends in objective and subjective sleep disturbances and cognition from early adulthood to the oldest old; 2) Evaluate the longitudinal association between sleep disturbances at different stages of life and cognitive performance over the life course including incident ADRD; 3) Elucidate and compare novel pathways linking sleep disturbances to ADRD at different stages of life. The research is highly significant because it helps to address the timing of sleep disturbances in relation to cognitive aging over the life course and thus the directionality of the relationship. The creation of the first-ever synthesized diverse cohort of sleep and cognition across the life course will also develop foundational resources for future research to disentangle the bi-directional link between sleep and ADRD. This work has a large impact as a critical step towards elucidating the role of life- course sleep disturbance as a prodromal or modifiable risk factor for ADRD. This will directly inform the early detection of ADRD and the design of intervention trials, especially in establishing the optimal timing for sleep intervention to mitigate dementia risk, a topic with profound public health implications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $690,284 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	3	3/20/2026	NON-COMPETING CONTINUATION	$690,284
														Subtotal = $690,284

Issue Date FY: 2025 ( Subtotal = $684,403 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	2	3/20/2025	NON-COMPETING CONTINUATION	$628,534
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	001	2	6/10/2025	NON-COMPETING CONTINUATION	$55,869
														Subtotal = $684,403

Issue Date FY: 2024 ( Subtotal = $729,553 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	1	5/15/2024	NEW	$729,553
														Subtotal = $729,553

Grand Total All Awards = $2,104,240

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Lifecourse sleep, cognitive decline and risk of Alzheimer's disease: a pooled cohort study.

Award Number: R01AG083836

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer