Wednesday, July 2, 2025 7/2/2025

Understanding the role of the cerebral microvasculature in brain aging

Award Number: R01AG083567
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Understanding the role of the cerebral microvasculature in brain aging - PROJECT SUMMARY/ABSTRACT Aging is one of the major risk factors for the development and progression of cerebrovascular, cardiovascular, and neurodegenerative diseases, contributing to long-term disability and mortality in the elderly. Aging- associated progressive structural and functional decline of vascular cells lead to vascular dysfunction such as decreased cerebral blood flow. While the vasculature is one of the most important targets of aging, it is not clear whether accumulating vascular pathologies or aging drives vascular dysfunction. The overall long-term goal of this project is to elucidate aging, and brain hypoperfusion-associated temporal changes in the cerebral vasculature. We will test the hypothesis that brain hypoperfusion exacerbates aging-associated compromised blood-brain-barrier integrity facilitated by mitochondrial dysfunction. To test our overall hypothesis, we proposed two specific aims. We will use young and old, male, and female mito-Dendra2 expressing and wild type mice in the proposed studies. Bilateral common carotid artery stenosis (BCAS) will be used to mimic cerebral hypoperfusion. The therapeutic potential of vascular mitochondria will be tested using a mitochondria targeted tetrapeptide. Two-photon microscopy will be used to determine how hypoperfusion exacerbates aging-associated BBB dysfunction in vivo, to map the brain vasculature, and vascular mitochondrial dynamics real time. Our studies will be complemented with immunofluorescence studies, discovery-based proteomics approach, and Western blot. The proposed research will reveal how aging and cerebral hypoperfusion affect endothelial mitochondria, and will elucidate mechanisms that might contribute to aging-related pathologies such as Alzheimer’s disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $552,968 )
2025	2025	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Aging Research	001	3	6/12/2025	NON-COMPETING CONTINUATION	$45,141
2025	2025	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Aging Research	000	3	4/17/2025	NON-COMPETING CONTINUATION	$507,827
														Subtotal = $552,968

Issue Date FY: 2024 ( Subtotal = $576,493 )
2024	2024	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Aging Research	000	2	5/10/2024	NON-COMPETING CONTINUATION	$576,493
														Subtotal = $576,493

Issue Date FY: 2023 ( Subtotal = $588,733 )
2023	2023	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Aging Research	000	1	7/31/2023	NEW	$588,733
														Subtotal = $588,733

Grand Total All Awards = $1,718,194

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Understanding the role of the cerebral microvasculature in brain aging

Award Number: R01AG083567

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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