Thursday, July 3, 2025 7/3/2025

The San Antonio Heart and Mind Study

Award Number: R01AG082360
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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The San Antonio Heart and Mind Study - ABSTRACT Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD) disproportionately affect minoritized populations. Compared to non-Hispanic Whites, older Hispanic adults in the United States are estimated to have a 50% increased risk of AD and are projected to bear the largest relative increase in AD/ADRD cases by 2060. Mexican Americans not only represent the largest segment of Hispanics in the United States, but they also experience a high burden of cardiometabolic diseases, which has the potential to increase AD/ADRD disparities over the next decades. However, Hispanics are underrepresented in epidemiological settings and more research is needed on this ethnic group to identify the factors contributing to AD/ADRD disparities. In this project, we propose to re-establish an epidemiological cohort initiated in 1979 to study ethnic differences in diabetes and cardiovascular disease. The San Antonio Heart Study enrolled 5,158 Mexican American and non-Hispanic White adults from socioculturally diverse neighborhoods in San Antonio, Texas. Through this grant, survivors will be invited to a new study focused on cognitive aging and AD/ADRD: The San Antonio Heart and Mind Study (SAHMS). We will perform comprehensive assessments for cognitive function, brain MRI, amyloid and tau PET, the measurement of blood- and CSF-based biomarkers, cardiometabolic disease, psychosocial attributes, and sociocultural factors. Participants will also be invited to our brain donation program for further neuropathological characterization. By leveraging the rich set of longitudinal data obtained four decades ago and newly collected information through this grant, we have an ideal setting to better understand the role of midlife and late-life factors contributing to AD/ADRD disparities in Mexican American older adults. Our talented multidisciplinary team offers complementary expertise for the success of this project. Results from our study have the potential to inform health policies aiming to prevent and delay AD/ADRD over the next decades, especially in the underserved population of Mexican Americans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,535,113 )
2025	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	3	6/10/2025	NON-COMPETING CONTINUATION	$288,581
2025	2025	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	3	3/20/2025	NON-COMPETING CONTINUATION	$3,246,532
														Subtotal = $3,535,113

Issue Date FY: 2024 ( Subtotal = $3,578,460 )
2024	2024	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	2	3/13/2024	NON-COMPETING CONTINUATION	$3,220,614
2024	2024	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	001	2	6/14/2024	NON-COMPETING CONTINUATION	$357,846
														Subtotal = $3,578,460

Issue Date FY: 2023 ( Subtotal = $2,173,170 )
2023	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Aging Research	000	1	6/20/2023	NEW	$2,173,170
														Subtotal = $2,173,170

Grand Total All Awards = $9,286,743

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The San Antonio Heart and Mind Study

Award Number: R01AG082360

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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