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Neural Stem Cell Aging and Neurodegeneration

Award Number: R01AG082105
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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Neural Stem Cell Aging and Neurodegeneration - Project Summary Perturbation of mitochondrial proteostasis, a form of mitochondrial stress, activates the mitochondrial unfolded protein response (UPRmt), a retrograde signaling pathway leading to transcriptional up-regulation of mitochondrial chaperones and stress relief. Recent advances in mitochondrial biology link UPRmt to lifespan extension independently of oxidative stress and damage in model organisms. These observations beg the questions of whether mitochondrial protein folding stress and the UPRmt regulate healthspan and lifespan in mammals. We have recently identified a novel regulatory branch of the UPRmt. We will elucidate the physiological significance of this pathway in regulating stem cell aging, tissue degeneration, and degenerative diseases, such as Alzheimer’s disease. Using a gain-of-function approach, we will test the feasibility of activating these molecules to extend healthspan during natural aging and ameliorate Alzheimer’s disease. Collectively, these studies highlight a novel defense program that improves mitochondrial integrity and tissue homeostasis. Successful completion of the proposed studies will provide a critical mechanistic understanding of how mitochondria and metabolism regulate tissue homeostasis. In addition to generating important basic knowledge, these studies will provide new targets for developing potential interventions for aging and aging- associated diseases, including Alzheimer’s disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $589,967 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	119 CALIFORNIA HALL	BERKELEY	CA	94720	ALAMEDA	USA	Aging Research	001	3	2/25/2026	NON-COMPETING CONTINUATION	$58,997
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	000	3	1/30/2026	NON-COMPETING CONTINUATION	$530,970
														Subtotal = $589,967

Issue Date FY: 2025 ( Subtotal = $530,981 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	001	2	7/15/2025	NON-COMPETING CONTINUATION	$43,346
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	000	2	11/27/2024	NON-COMPETING CONTINUATION	$487,635
														Subtotal = $530,981

Issue Date FY: 2024 ( Subtotal = $541,817 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Aging Research	000	1	2/16/2024	NEW	$541,817
														Subtotal = $541,817

Grand Total All Awards = $1,662,765

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Neural Stem Cell Aging and Neurodegeneration

Award Number: R01AG082105

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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