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The impact of interpersonal stressors and residential stressors on chronic pain in older adults: neurobiological and psychological mechanisms

Award Number: R01AG081479
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2028

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The impact of interpersonal stressors and residential stressors on chronic pain in older adults: neurobiological and psychological mechanisms - In the United States, older adults are more likely to experience chronic pain and related decline in physical functioning. Evidence suggests that exposure to both interpersonal and residential stressors may contribute to the development and progression of chronic pain. The psychological and neurobiological mechanisms through which these stressors influence pain outcomes—and to what extent they overlap-- remain insufficiently understood. Clarifying these mechanisms is critical to identifying modifiable factors that could improve pain management strategies for older adults. We hypothesize that residential stressors (e.g., limited neighborhood resources) and interpersonal stressors (e.g., negative social interactions) affect chronic pain outcomes through at least partially distinct psychosocial and neurobiological pathways. Our rationale is that such stressors influence interconnected biological and psychological systems, potentially accelerating the progression of musculoskeletal pain and related decreased physical function. We will test this central hypothesis through three specific aims: (1) Evaluate the independent and combined effects of residential and interpersonal stressors on chronic pain outcomes; (2) Identify psychosocial and biological mediators linking these stressors to pain outcomes; and (3) Examine individual-level protective factors that may buffer the psychological and biological effects of these stressors. Residential stress will be assessed using objective measures of neighborhood resource availability (e.g., Area Deprivation Index). Interpersonal stress will include perceived and observed experiences of negative social interactions. This research is innovative in its integration of multiple stress domains, mechanistic pathways, and protective factors. It is expected to improve our understanding of how different forms of stress contribute to chronic pain in older adults, ultimately informing strategies to improve outcomes in aging populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $713,148 )
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	001	4	3/2/2026	NON-COMPETING CONTINUATION	$71,314
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	000	4	1/22/2026	NON-COMPETING CONTINUATION	$641,834
														Subtotal = $713,148

Issue Date FY: 2025 ( Subtotal = $715,764 )
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	001	3	9/18/2025	NON-COMPETING CONTINUATION	$58,429
2025	2025	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	000	3	2/14/2025	NON-COMPETING CONTINUATION	$657,335
														Subtotal = $715,764

Issue Date FY: 2024 ( Subtotal = $748,240 )
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	000	2	1/18/2024	NON-COMPETING CONTINUATION	$673,416
2024	2024	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	001	2	6/11/2024	NON-COMPETING CONTINUATION	$74,824
														Subtotal = $748,240

Issue Date FY: 2023 ( Subtotal = $775,704 )
2023	2023	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	000	1	3/24/2023	NEW	$775,704
														Subtotal = $775,704

Grand Total All Awards = $2,952,856

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The impact of interpersonal stressors and residential stressors on chronic pain in older adults: neurobiological and psychological mechanisms

Award Number: R01AG081479

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2028

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