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Feasibility of Improving Glycemia to Prevent Alzheimer's Disease

Award Number: R01AG081304
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Feasibility of Improving Glycemia to Prevent Alzheimer's Disease - Project Summary The impaired glycemic control associated with pre-diabetes increases risk for type 2 diabetes, which is a known risk factor for Alzheimer’s Disease (AD). Mechanisms such as impaired energy metabolism, cellular bioenergetic function, reduced intracellular protein homeostasis (proteostasis), and inflammation are all potential contributors to AD etiology. Therefore, a novel therapy that simultaneously improves glycemic control and cellular chaperone systems (i.e. Heat Shock Proteins, HSPs) may prove particularly effective in preventing and treating AD. Heat therapy has been independently shown to improve blood glucose regulation, insulin resistance, and inflammation. Importantly, heat therapy also activates inter-organ crosstalk via endocytic vesicles and increases HSPs to improve both mitochondrial function and proteostasis in a variety of tissues. Given the potential contribution of these factors to brain health, heat therapy could offer immense clinical benefit to individuals at risk for AD. Here, we will determine if heat therapy can improve blood (Aim 1) and brain (Aim 2) glucose metabolism in cognitively healthy older adults (65+) who are at risk for AD. We will also examine the degree to which changes in blood and brain glucose metabolism track together and explore several additional potential mechanisms that are critical to understanding the brain benefits of heat therapy (Aim 3). These aims will provide a comprehensive understanding of the impact of heat therapy on glucose homeostasis and brain health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $463,492 )
2025	2025	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Aging Research	000	3	5/29/2025	NON-COMPETING CONTINUATION	$463,492
														Subtotal = $463,492

Issue Date FY: 2024 ( Subtotal = $472,952 )
2024	2024	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Aging Research	000	2	6/10/2024	NON-COMPETING CONTINUATION	$472,952
														Subtotal = $472,952

Issue Date FY: 2023 ( Subtotal = $477,602 )
2023	2023	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Aging Research	001	1	9/20/2023	NEW	$0
2023	2023	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Aging Research	000	1	4/28/2023	NEW	$477,602
														Subtotal = $477,602

Grand Total All Awards = $1,414,046

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Feasibility of Improving Glycemia to Prevent Alzheimer's Disease

Award Number: R01AG081304

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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