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Move and Snooze: Adding insomnia treatment to an exercise program to improve pain outcomes in older adults with knee osteoarthritis

Award Number: R01AG081299
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Move and Snooze: Adding insomnia treatment to an exercise program to improve pain outcomes in older adults with knee osteoarthritis - Osteoarthritis (OA) affects an estimated 32.5 million US adults and up to 50% of those aged over 65; over 80% of this burden is attributable to knee OA. Pain is consistently identified as the most troublesome symptom for people living with knee OA, with higher pain intensity associated with reduced muscle strength, activity limitations, and reduced quality of life. Exercise is central in clinical practice guidelines for knee OA pain management; however, evidence synthesis has demonstrated variable and, overall, modest effects. Observational studies have indicated that the pain-relieving effects of exercise may be modulated by sleep disturbances, including symptoms of insomnia, thus providing one possible explanation for the variable effect of exercise on OA pain reduction. This information is especially critical given that an estimated 70% of older adults with knee OA report having problems with sleep. This study is based on the premise that improving sleep may improve the pain-relieving benefits of exercise for knee OA. Informed by existing evidence and focus groups conducted with people living with OA and sleep disturbances, we developed and subsequently feasibility-tested a hybrid exercise and sleep improvement intervention for OA pain management (Move and Snooze). The intervention combines a personalized exercise program with an automated and digitally delivered evidence-based course of Cognitive Behavioral Therapy for Insomnia (CBT-I). The primary aim of this clinical trial is to determine the effectiveness of the eight-week hybrid program on knee OA pain reduction. Participants will be randomized to receive the hybrid intervention (personalized exercise program + CBT-I) or the personalized exercise program alone. In addition to determining effectiveness, we will investigate whether specific characteristics identify individuals who derive particular benefit from the hybrid intervention. Specifically, we will determine whether insomnia symptoms need to exceed a specific threshold for provision of the sleep-enhanced exercise program to be warranted and will examine whether the intervention is more effective for people presenting with indication of centralized pain (as opposed to predominantly peripheral pain). We will also determine whether pre-specified psychological factors (e.g., symptoms of depression and anxiety) alter the effectiveness of the intervention. Finally, as we will collect data on hypothesized possible mediators of the intervention throughout the course of the trial (e.g., pain vigilance and awareness; positive and negative affect; fatigue intensity), we will apply contemporary causal inference methods to determine pathways by which the hybrid intervention, and exercise alone, exert their effects on changes in pain. This research will generate evidence to advance osteoarthritis pain management towards greater efficacy and personalization, serving our long-term goal of improving pain outcomes for the vast and growing number of people living with OA by identifying the most appropriate behavior change interventions for specific patient phenotypes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $728,103 )
2026	2026	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	4	7/21/2026	NON-COMPETING CONTINUATION	$728,103
														Subtotal = $728,103

Issue Date FY: 2025 ( Subtotal = $727,607 )
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	3	7/31/2025	NON-COMPETING CONTINUATION	$727,607
														Subtotal = $727,607

Issue Date FY: 2024 ( Subtotal = $754,467 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	001	2	6/28/2024	NON-COMPETING CONTINUATION	$754,467
2024	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	1	1/17/2024	NEW	$0
														Subtotal = $754,467

Issue Date FY: 2023 ( Subtotal = $779,516 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Aging Research	000	1	9/21/2023	NEW	$779,516
														Subtotal = $779,516

Grand Total All Awards = $2,989,693

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Move and Snooze: Adding insomnia treatment to an exercise program to improve pain outcomes in older adults with knee osteoarthritis

Award Number: R01AG081299

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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