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Longitudinal impact of midlife cerebrovascular pulsatility on brain tissue integrity and cognitive aging

Award Number: R01AG080052
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Longitudinal impact of midlife cerebrovascular pulsatility on brain tissue integrity and cognitive aging - PROJECT SUMMARY Normal aging is associated with a gradual decline in cognitive abilities across the lifespan, which is accelerated by midlife vascular risk factors, including stiffening of the large elastic arteries. The purpose of this project is to determine whether arterial stiffness is an early contributor to cognitive aging through the transmission of damaging pulsatile energy into the brain. Magnetic resonance elastography (MRE) is a non-invasive imaging modality that detects the viscoelastic properties of tissue and serves as a sensitive biomarker of brain tissue health and microstructural integrity. MRE has shown that brain tissue softening occurs with normal aging and likely precedes gross tissue atrophy. This 3-year longitudinal study seeks to determine the underlying mechanisms linking midlife vascular risk factors with the early loss of brain tissue structure and function. We will (1) determine the early mechanisms leading to age-related increases in cerebrovascular pulsatility, (2) determine whether changes in cerebrovascular pulsatility and brain tissue viscoelasticity are spatially and temporally correlated, and (3) determine whether cerebrovascular pulsatility mediates the loss of cognitive performance through the disruption of specific neuronal substrates important for memory performance (i.e., the hippocampus). Ultimately, this project will identify the earliest underlying mechanisms by which vascular aging contributes to the loss of brain tissue integrity and cognitive performance leading to new targets for interventions aimed at preventing age-related cognitive impairment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $768,457 )
2026	2026	UNIVERSITY OF DELAWARE	550 S COLLEGE AVE	NEWARK	DE	19713	NEW CASTLE	USA	Aging Research	000	3	6/4/2026	NON-COMPETING CONTINUATION	$768,457
														Subtotal = $768,457

Issue Date FY: 2025 ( Subtotal = $764,294 )
2025	2025	UNIVERSITY OF DELAWARE	550 S COLLEGE AVE	NEWARK	DE	19713	NEW CASTLE	USA	Aging Research	000	2	6/26/2025	NON-COMPETING CONTINUATION	$764,294
														Subtotal = $764,294

Issue Date FY: 2024 ( Subtotal = $768,427 )
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Aging Research	000	1	9/10/2024	NEW	$768,427
														Subtotal = $768,427

Grand Total All Awards = $2,301,178

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Longitudinal impact of midlife cerebrovascular pulsatility on brain tissue integrity and cognitive aging

Award Number: R01AG080052

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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