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MIND Foods and Aerobic Training in Black Adults with HTN: An ADRD Prevention Pilot RCT (MAT)

Award Number: R01AG076685
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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MIND Foods and Aerobic Training in Black Adults with HTN: An ADRD Prevention Pilot RCT (MAT) - ABSTRACT Hypertension rates among middle-aged non-Hispanic black (NHB) adults are among the highest in the world, which is a significant source of racial disparities in ADRD. In September 2020, two NIH directors recommended safety-net health care providers and patients and scientists co-design novel interventions to alleviate racial and socioeconomic disparities in hypertension. Also in 2020, the Lancet Commission on dementia prevention noted that lifestyle interventions may be particularly efficacious for ADRD prevention in subpopulations with high cardiovascular disease risk. This evidence points to a significant need for behavioral intervention co-design with subpopulations at high cardiovascular risk. Thus, we worked with safety-net primary care providers and NHB patients to iteratively co-design an intervention to support hypertension self-management and Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) diet and aerobic training (MAT). Due to the co-design process, MAT addresses patient and safety-net provider preferences and thus may be an engaging and sustainable strategy in an externally valid setting for the promotion of MIND diet and aerobic activity in a very high-risk subpopulation. MAT is also likely to be potent as over 50% of CVD among NHB adults has been attributed to poor diet and fitness, which contribute greatly to ADRD disparities. MAT involves our CDC-endorsed hypertension self-management education and support classes followed by home-delivered MIND food ingredients and twice-weekly MIND cooking, nutrition, and aerobic activity via videoconference. This novel intervention has not been evaluated for its effects on cognition. In an early stage randomized controlled trial, we aim to demonstrate feasibility and investigate MAT effects on cognition. We propose to test, in a Stage IB pilot RCT, MAT versus our attention control intervention (AC). We will randomize 128 NHB safety-net primary care patients with high systolic blood pressure (≥140 mm Hg) to 28wks of AC or MAT. Provider-led MAT is 28wks followed by 24wks of self-led MAT. Measures will be at baseline, post-treatment (28 weeks), and follow-up (52 weeks). We will measure feasibility and cognition. We will also explore intervention processes and obtain and store blood samples for possible future analyses. A successful pilot would support a follow-on ADRD prevention trial across safety-net primary care sites with the objectives of ADRD prevention and reduction of ADRD disparities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $618,366 )
2026	2026	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	4	2/6/2026	NON-COMPETING CONTINUATION	$556,529
2026	2026	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	4	2/25/2026	NON-COMPETING CONTINUATION	$61,837
														Subtotal = $618,366

Issue Date FY: 2025 ( Subtotal = $624,493 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	3	4/2/2025	NON-COMPETING CONTINUATION	$573,513
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	3	6/13/2025	NON-COMPETING CONTINUATION	$50,980
														Subtotal = $624,493

Issue Date FY: 2024 ( Subtotal = $644,022 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	001	2	3/1/2024	NON-COMPETING CONTINUATION	$579,619
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	002	2	7/3/2024	NON-COMPETING CONTINUATION	$64,403
2024	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	1	10/18/2023	NEW	$0
														Subtotal = $644,022

Issue Date FY: 2023 ( Subtotal = $686,422 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Aging Research	000	1	3/7/2023	NEW	$686,422
														Subtotal = $686,422

Grand Total All Awards = $2,573,303

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MIND Foods and Aerobic Training in Black Adults with HTN: An ADRD Prevention Pilot RCT (MAT)

Award Number: R01AG076685

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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